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Gene Expression Data
Assay Details
Assay
Reference: J:98688 Tang LS, et al., Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear. Gene Expr Patterns. 2005 Jun;5(5):587-92
Assay type: RNA in situ
MGI Accession ID: MGI:5907891
Gene symbol: Nr2f1
Gene name: nuclear receptor subfamily 2, group F, member 1
Probe: Erbal3 cDNA2
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 8.75 (more )
Structure Level Pattern Image Note
TS14: otic placode epithelium Present Regionally restricted 1A Earliest expression at E8.75 (17 somites) in ventral-anterior domain of otic placode epithelium.
TS14: 1st branchial arch Present 1A
TS14: 2nd branchial arch Present 1A

Specimen 1B: embryonic day 9.75 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 1B Authors state expression in otic vesicle expanded posteriorly.
TS15: 1st branchial arch Present 1B
TS15: 2nd branchial arch Present 1B

Specimen 1C: embryonic day 9.75 (more )
Structure Level Pattern Image Note
TS15: otocyst Strong Regionally restricted 1C In 26 somite embryos, strong expression in ventral-posterior domain of otic vesicle.

Specimen 1D: embryonic day 9.75 (more )
Structure Level Pattern Image Note
TS15: otocyst epithelium Present Regionally restricted 1D Expression in the posterior quadrant with higher levels at the lateral epithelium.

Specimen E13.5 not shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cochlear duct epithelium Present Widespread Between E10 and E13.5, expression throughout multi-layered sensory epithelium of elongating cochlear duct from base to apex.

Specimen 2A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: greater epithelial ridge Present Regionally restricted 2A Between E14.5 and E15.5, expression becomes more confined to greater epithelial ridge of sensory epithelium in apical coil.

Specimen 2B: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: greater epithelial ridge Strong 2B
TS23: lesser epithelial ridge Ambiguous 2B Clear demarcation at border with lesser epithelium ridge at the apical coil.
TS23: cochlear duct epithelium Present Regionally restricted 2B Expression also in medial wall opposing the sensory epithelium.

Specimen 2C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 2C As sensory epithelium develops along length of cochlear duct, relative expression levels decreases.
TS23: greater epithelial ridge Present 2C Expression domain extends beyond greater epitheial ridge to lesser epithelial ridge.
TS23: lesser epithelial ridge Present 2C Expression domain extends beyond greater epitheial ridge to lesser epithelial ridge.

Specimen 2D: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Weak Regionally restricted 2D As development proceeds in apical to basal direction, relative expression level decreases in sensory epithelium.
TS23: greater epithelial ridge Present 2D Expression domain extends beyond greater epitheial ridge to lesser epithelial ridge.
TS23: lesser epithelial ridge Present 2D Expression domain extends beyond greater epitheial ridge to lesser epithelial ridge.

Specimen 2E: embryonic day 15.5; Nr2f1tm1Mjts/Nr2f1tm1Mjts (more )
Structure Level Pattern Image Note
TS23: cochlea Absent 2E


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory