Rbfox3 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:240500 Lopez-Domenech G, et al., Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites. Cell Rep. 2016 Oct 04;17(2):317-327
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:5906607
Gene symbol:	Rbfox3
Gene name:	RNA binding protein, fox-1 homolog (C. elegans) 3

Antibody:

Results

5A WT merge ©

5A WT NeuN ©

Specimen 5A NeuN WT 8 months: postnatal month 8; Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS28: hippocampus CA1	Present		5A WT NeuN , 5A WT merge

Specimen 5A NeuN Miro1cko 8 months: postnatal month 8; Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi}, Tg(Camk2a-cre)1Gsc/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: hippocampus CA1	Present		5A Miro1cko merge , 5A Miro1cko NeuN	No significant loss of neurons detected by NeuN (Rbfox3) expression.

Specimen 5B WT graph: postnatal month 8; Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi} (more

)

Specimen 5B Miro1cko graph: postnatal month 8; Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi}, Tg(Camk2a-cre)1Gsc/0 (more

)
Note: Conditional mutant.

Structure	Level	Note
TS28: cerebral cortex	Present	The number of staining cells in the mutant is comparable to the number seen in wild type.
TS28: hippocampus CA1	Present	The number of staining cells in the mutant is comparable to the number seen in wild type.
TS28: hippocampus CA3	Present	The number of staining cells in the mutant is comparable to the number seen in wild type.

Specimen 5B Miro2ko graph: postnatal month 8; Rhot2^{tm1(KOMP)Wtsi}/Rhot2^{tm1(KOMP)Wtsi} (more

)

Structure	Level	Note
TS28: cerebral cortex	Present	The number of staining cells in the mutant is comparable to the number seen in wild type.
TS28: hippocampus CA1	Present	The number of staining cells in the mutant is comparable to the number seen in wild type.
TS28: hippocampus CA3	Present	The number of staining cells in the mutant is comparable to the number seen in wild type.

5C WT merge ©

5C WT NeuN ©

Specimen 5C NeuN WT 12 months: postnatal month 12; Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS28: hippocampus CA1	Present		5C WT NeuN , 5C WT merge

Specimen 5C NeuN Miro1cko 12 months: postnatal month 12; Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi}, Tg(Camk2a-cre)1Gsc/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: hippocampus CA1	Weak		5C Miro1cko NeuN , 5C Miro1cko merge	Enhanced loss of dendritic tree in CA1 pyramidal neurons compared to wildtype brains.

Specimen 5D WT graph: postnatal month 12; Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi} (more

)

Specimen 5D Miro1cko graph: postnatal month 12; Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi}, Tg(Camk2a-cre)1Gsc/0 (more

)
Note: Conditional mutant.

Structure	Level	Note
TS28: cerebral cortex	Present	The number of staining cells is reduced in the mutant.
TS28: hippocampus CA1	Present	The number of staining cells is reduced in the mutant.
TS28: hippocampus CA3	Present	The number of staining cells is reduced in the mutant.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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