About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:240579 Howard SR, et al., IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. EMBO Mol Med. 2016 Jun;8(6):626-42
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5903411
Gene symbol: Gnrh1
Gene name: gonadotropin releasing hormone 1
Antibody: Anti-GnRH/LHRH (20075)
Detection system: Secondary antibody
Results
Specimen 4B/C: embryonic day 12.5 (more )
Note: Double labeled: brown - Gnrh1; purple - Igsf10 (assay MGI:5903409).
Structure Level Pattern Image Note
TS20: nasal mesenchyme Present Regionally restricted 4C , 4B Expressed in neurons exiting the vomeronasal organ and migrating into an Igsf10 strongly positive cell milieu in the nasal mesenchyme.
TS20: nerve Present Regionally restricted 4C , 4B Expressed in neurons exiting the vomeronasal organ and migrating into an Igsf10 strongly positive cell milieu in the nasal mesenchyme.

Specimen 4D: embryonic day 14.5 (more )
Note: Double labeled: brown - Gnrh1; purple - Igsf10 (assay MGI:5903409).
Structure Level Pattern Image Note
TS22: nasal mesenchyme Present Regionally restricted 4D Expressed in neurons navigating among the Igsf10-positive nasal mesenchyme cells.
TS22: nerve Present Regionally restricted 4D Expressed in neurons navigating among the Igsf10-positive nasal mesenchyme cells.

Specimen 4J: embryonic day 17.5 (more )
Note: Double labeled: brown - Gnrh1; purple - Igsf10 (assay MGI:5903409).
Structure Level Pattern Image Note
TS25: nerve Present Regionally restricted 4J Expressed in neurons located in the medial preoptic area in an Igsf10-negative area.
TS25: preoptic area Present Regionally restricted 4J Expressed in neurons located in the medial preoptic area in an Igsf10-negative area.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory