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Gene Expression Data
Assay Details
Assay
Reference: J:14524 Clauss IM, et al., In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun;197(2):146-56
Assay type: RNA in situ
MGI Accession ID: MGI:5816634
Gene symbol: Timp1
Gene name: tissue inhibitor of metalloproteinase 1
Probe: TIMP probe1
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Assay notes: Specimens were embedded in paraffin or processed for cryosectioning; authors did not specify which.
Results
Specimen day 10.5 not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: embryo Absent

Specimen 3A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: pectoral-thoracic pre-cartilage condensation Present Regionally restricted 3A Expression in cartilaginous ribs.
TS19: skeleton Present Regionally restricted 3A Expression in the bony clavicle.

Specimen 3B/C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: skeleton Present Regionally restricted 3B/C Expression in periosteal cuff of bone forming the diaphysis. Expression principally in chondroblasts of mature zone of growth cartilage. Much lower levels of expression in chondroblasts than in osteoblasts.

Specimen 3E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: rib cartilage condensation Present Regionally restricted 3E Expression in osteoblasts of periosteal cuff of bone of rib cortex.

Specimen 3F/G: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: femur Strong Regionally restricted 3F/G High levels of expression in periosteal derived osteoblasts of bony diaphysis, and in osteoblasts participating in endochondral ossification. No expression in hypertrophic and degenerative cartilage cells.

Specimen 3H: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: maxilla Present Regionally restricted 3H Expression in the fine cancellous bone of maxilla. Expression persists in more mature osteoblasts. Most intense expression in preosteoblasts one or several cell layers from the osteoblasts of newly formed bones.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory