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Gene Expression Data
Assay Details
Assay
Reference: J:195918 Vieux-Rochas M, et al., BMP-mediated functional cooperation between Dlx5;Dlx6 and Msx1;Msx2 during mammalian limb development. PLoS One. 2013;8(1):e51700
Assay type: RNA in situ
MGI Accession ID: MGI:5810612
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 probe50
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 4A: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: forelimb bud apical ectodermal ridge Present 4A
TS18: forelimb bud mesenchyme Present Regionally restricted 4A Expression in anterior mesenchyme.
Specimen 4B: embryonic day 11.0; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi (more )
Note: This embryo was a single homozygote. However, since this allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS18: forelimb bud apical ectodermal ridge Present 4B
TS18: forelimb bud mesenchyme Present Regionally restricted 4B Expression in anterior mesenchyme unchanged compared with wild type.
Specimen 4C: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: hindlimb bud apical ectodermal ridge Present 4C
TS18: hindlimb bud mesenchyme Present Regionally restricted 4C Expression in anterior mesenchyme.
Specimen 4D: embryonic day 11.0; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi (more )
Note: This embryo was a single homozygote. However, since this allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS18: hindlimb bud apical ectodermal ridge Weak Regionally restricted 4D Expression decreased specifically in the central sector of AER in hindlimbs.
TS18: hindlimb bud mesenchyme Present Regionally restricted 4D Expression in anterior mesenchyme unchanged compared with wild type.
Specimen 4E: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: branchial arch Present 4E
Specimen 4F: embryonic day 11.0; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi (more )
Note: This embryo was a single homozygote. However, since this allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS18: branchial arch Present 4F Authors state that expression was retained in the pharyngeal arches region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory