Egr2 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:14491 Dolle P, et al., Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7666-70
Assay type:	RNA in situ
MGI Accession ID:	MGI:5805916
Gene symbol:	Egr2
Gene name:	early growth response 2

Results

Specimen 1a: embryonic day 8.5 (more

)

Structure	Level	Pattern	Image	Note
TS13: rhombomere 3	Present		1a brightfield/Krox
TS13: rhombomere 5	Present		1a brightfield/Krox

Specimen 1b: embryonic day 8.5; Hoxa1^tm1Ipc/Hoxa1^tm1Ipc (more

)

Structure	Level	Pattern	Image	Note
TS13: rhombomere 3	Present		1b brightfield/Krox

Specimen 2a: embryonic day 9.5 (more

)

Structure	Level	Pattern	Image	Note
TS15: rhombomere 5	Present		2a brightfield/Krox
TS15: rhombomere 3	Absent		2a brightfield/Krox	In most specimens expression has disappeared in rhombomere 3 at this age but in some specimens a remnant of expression remains (see figure 3a).

2c Krox ©

Specimen 2b: embryonic day 9.5; Hoxa1^tm1Ipc/Hoxa1^tm1Ipc (more

)
Note: (c) is a higher magnification of the boxed area in (b).

Structure	Level	Pattern	Image	Note
TS15: rhombomere 5	Present	Regionally restricted	2c Krox , 2b brightfield/Krox	Expression is in a thin stripe.
TS15: head mesenchyme derived from neural crest	Present	Regionally restricted	2c Krox , 2b brightfield/Krox	Expression is in a thin population.

3a Krox ©

Specimen 3a: embryonic day 9.5 (more

)

Structure	Level	Pattern	Image	Note
TS15: rhombomere 5	Strong		3a Krox
TS15: rhombomere 3	Weak		3a Krox	In some specimens expression has disappeared in rhombomere 3 at this age (see figure 2a) but in some specimens a remnant of expression remains.
TS15: head mesenchyme derived from neural crest	Present	Regionally restricted	3a Krox	Expression is in a thin neural crest population originating from rhombomere 5.

3b Krox ©

Specimen 3b: embryonic day 9.5; Hoxa1^tm1Ipc/Hoxa1^tm1Ipc (more

)

Structure	Level	Pattern	Image	Note
TS15: future hindbrain	Present	Regionally restricted	3b Krox	Expression is in a thin stripe in the dorsal area.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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