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Gene Expression Data
Assay Details
Assay
Reference: J:100495 Howard B, et al., Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev. 2005 Sep 1;19(17):2078-90
Assay type: RNA in situ
MGI Accession ID: MGI:5796675
Gene symbol: Nrg3
Gene name: neuregulin 3
Probe: Ngr3 probe1
Probe preparation: Antisense labelled with digoxigenin RNA
Assay notes: Authors state that 5 probes were generated (MGI:5796655, MGI:5796656, MGI:5796657, MGI:5796688 and MGI:5796659) and that all gave similar results.
Results
Specimen 3A: embryonic day 10.75 (more )
Note: 38 somites
Structure Level Pattern Image Note
TS17: mesenchyme derived from lateral plate Present Regionally restricted 3A Authors describe a comet of expression underlying future site of mammary bud 3 (at somite 18), spanning the level of somites 17-18.
Specimen 3B: embryonic day 11.0 (more )
Note: 41 somites
Structure Level Pattern Image Note
TS18: mesenchyme derived from lateral plate Present Regionally restricted 3B Dermal comet of expression surrounding future site of mammary bud 3 (at somite 18) and bud 4 (at somite 24).
Specimen 3C: embryonic day 11.0 (more )
Note: 41 somites
Structure Level Pattern Image Note
TS18: mesenchyme derived from lateral plate Present Regionally restricted 3C Expression surrounding future site of mammary bud 3 (at somite 18) and bud 4 (at somite 24).
Specimen 3D: embryonic day 11.0 (more )
Note: 41 somites
Structure Level Pattern Image Note
TS18: mesenchyme derived from lateral plate Present Regionally restricted 3D Expression surrounding future site of mammary bud 4 (at somite 24).
Specimen 3E: embryonic day 11.5 (more )
Note: 45 somites
Structure Level Pattern Image Note
TS19: mesenchyme derived from lateral plate Present Regionally restricted 3E Expression in dermal mesenchyme underlying where buds 3 and 4 will subsequently form.
Specimen 3F: embryonic day 11.5 (more )
Note: 45 somites
Structure Level Pattern Image Note
TS19: mesenchyme derived from lateral plate Present Regionally restricted 3F Expression in mesenchyme underlying nascent mammary anlage.
Specimen 3G: embryonic day 11.5 (more )
Note: 45 somties
Structure Level Pattern Image Note
TS19: mesenchyme derived from lateral plate Present Regionally restricted 3G Expression in lateral plate mesoderm around the anlage outlining a distinct bud shape.
Specimen 3H: embryonic day 11.75 (more )
Note: 47 somites
Structure Level Pattern Image Note
TS19: mammary placode Present Regionally restricted 3H Expression first detected in epithelia of nascent mammary anlage.
Specimen 3I: embryonic day 11.75 (more )
Note: 47 somites
Structure Level Pattern Image Note
TS19: mammary placode Present Regionally restricted 3I Expression in epithelia of bud 4
TS19: mesenchyme derived from lateral plate Present Regionally restricted 3I Expression in mesenchyme underlying future site of mammary bud 5. Localized expression detected in lateral plate mesoderm prior to the appearance of each bud.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory