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Gene Expression Data
Assay Details
Assay
Reference: J:133600 Aoki M, et al., R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development. Dev Growth Differ. 2008 Feb;50(2):85-95
Assay type: RNA in situ
MGI Accession ID: MGI:5788482
Gene symbol: Wnt7a
Gene name: wingless-type MMTV integration site family, member 7A
Probe: Wnt7a probe6
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 6A: embryonic day 10.5; Rspo2tm1Hoka/Rspo2tm1Hoka (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 6A Expression in mutant forelimbs in a similar pattern to that observed in wildtype forelimbs.
Specimen 6B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 6B
Specimen 6C: embryonic day 10.5; Rspo2tm1Hoka/Rspo2tm1Hoka (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present Regionally restricted 6C Expression extended into the ventral ectoderm at the anterior region in 3 or 5 forelimbs analyzed.
Specimen 6D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 6D
Specimen E11.5 mutant forelimb not shown: embryonic day 11.5; Rspo2tm1Hoka/Rspo2tm1Hoka (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present
Specimen E11.5 wildtype forelimb not shown: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present
Specimen 6E: embryonic day 10.5; Rspo2tm1Hoka/Rspo2tm1Hoka (more )
Structure Level Pattern Image Note
TS17: hindlimb bud ectoderm Present Regionally restricted 6E Border of expression unclear, probably due to extension of expression into ventral ectoderm.
Specimen 6F: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindlimb bud ectoderm Present 6F
Specimen E11.5 mutant hindlimb not shown: embryonic day 11.5; Rspo2tm1Hoka/Rspo2tm1Hoka (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present
Specimen E11.5 wildtupe hindlimb: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory