About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:130971 Hasegawa H, et al., Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. J Neurosci. 2007 Dec 26;27(52):14404-14
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5767327
Gene symbol: Avil
Gene name: advillin
Reporter: alkaline phosphatase
Direct Detection
Results
Specimen 3Aa: embryonic day 12.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS20: trigeminal ganglion Present 3Aa Expression in subsets of neurons at E12.5.

Specimen 3Ab: embryonic day 14.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS22: trigeminal ganglion Present 3Ab Gradual increase in both the number and staining intensity in all trigeminal neurons.

Specimen 3Ac: embryonic day 16.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS24: trigeminal ganglion Strong 3Ac Maximum intensity of expression at E16.5.

Specimen 3Ad: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: trigeminal ganglion Strong 3Ad

Specimen 3Ca/Cc: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Double labeled: purple - Avil reporter: green - PGP9.5 (Uchl1 assay MGI:5767324).
Structure Level Pattern Image Note
TS27: facial nerve Absent 3Ca , 3Cc No expression in facial motor axons innervating muscles at the bottom of whiskers.

Specimen 4Aa: postnatal adult; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS28: hand skin Present Regionally restricted 4Aa In glabrous skin, expression in various types of nociceptive and mechanosensory endings.

Specimen 4Ab: postnatal adult; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS28: hand skin Present Regionally restricted 4Ab In glabrous skin, expression in various types of nociceptive and mechanosensory endings.

Specimen 4Ac: postnatal adult; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS28: hand skin Present Regionally restricted 4Ac Expression in Meissners corpuscles.

Specimen 4Ad: postnatal adult; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS28: hand skin Present Regionally restricted 4Ad Expression Merkel endings.

Specimen 4Ae: postnatal adult; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS28: hand skin Present Regionally restricted 4Ae Expression in Krauses end bulbs and free nerve endings.

Specimen 4Af: postnatal adult; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS28: hand skin Present Regionally restricted 4Af Expression in Pacinian corpuscles.

Specimen 4Ag: postnatal adult; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS28: back skin Present Regionally restricted 4Ag In hairy skin, expression in axons innervating guard hair follicles, but not in subset of vellus hairs not innervated by sensory axons.

Specimen 4Ba: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: skeletal muscle Present Regionally restricted 4Ba Expression in proprioceptive innervation of muscle spindles.

Specimen 4Bb: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: skeletal muscle Present Regionally restricted 4Bb Expression in proprioceptive innervation of Golgi tendons.

Specimen 4Ca: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: eyelid Present Regionally restricted 4Ca Authors describe a boundary between the upper and lower lids where there is a dense innervation by expressing axons.
TS27: cornea Present 4Ca

Specimen 4Da: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: soft palate Present Regionally restricted 4Da Expression in facial, glossopharyngeal and vagus nerves innervating taste buds in the upper soft palate.

Specimen 4Db: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: tongue papillae Present Regionally restricted 4Db Authors report expression in in filiate papillae.
TS27: temporo-mandibular joint Present Regionally restricted 4Db Expression in Ruffini endings and Golgi-Mazzoni corpuscles of trigeminal mandibular axons innervating the temporomandibular joint.

Specimen 4Dc: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: fungiform papillae Present 4Dc

Specimen 4Dd: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: circumvallate papillae Present 4Dd

Specimen 5Aa: embryonic day 12.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS20: mystacial pad Present Regionally restricted 5Aa Most axons form a plexus at the developing follicular-sinus complex, which are presumptive deep vibrissal nerve axons.
TS20: face skin Present Regionally restricted 5Aa No expression in surface skin between each whisker.

Specimen 5Ab: embryonic day 14.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS22: mystacial pad Present Regionally restricted 5Ab Expression in nociceptive axons tips first found at E14.5 at surface skin between each whisker.

Specimen 5Ac: embryonic day 16.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS24: mystacial pad Present Regionally restricted 5Ac Expression in Merkel endings at the ring sinus level.

Specimen 5Ad: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted 5Ad Expression in Merkel endings and transverse lanceolate endings, but not other types of endings.

Specimen 5Ba: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted 5Ba Expression in trigeminal axons innervating the small whiskers.

Specimen 5Bb: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted 5Bb Expression in mechanosensory Merkel endings, transverse and longitudinal lanceolate endings, and nociceptive circumferential free endings.

Specimen E12.5 not shown: embryonic day 12.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS20: forelimb interdigital region Present Regionally restricted Expression in sensory axons projecting into limb buds as fascicles running in the middle of developing digits.

Specimen 5Ca: embryonic day 14.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS22: hand skin Present Regionally restricted 5Ca Expression in sensory axons forming a plexus uderneath presumptive dermal ridges.

Specimen 5Cb: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: hand skin Present Regionally restricted 5Cb Expression in innervations that are distributed to cover the entire skin, but have not formed specialized nerve endings.

Specimen 6Aa: embryonic day 12.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Section of brainstem at level of principle trigeminal nucleus (Pr5).
Structure Level Pattern Image Note
TS20: trigeminal nerve Present Regionally restricted 6Aa Expression in main central axons of trigeminal ganglion neurons forming the trigeminal tract alongside the hindbrain. Essentially no collaterals sprouting into the central nuclei.

Specimen 6Ab: embryonic day 12.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Section of brainstem at level of spinal trigeminal nuclei (Sp5).
Structure Level Pattern Image Note
TS20: trigeminal nerve Present Regionally restricted 6Ab Very few trigeminal axons innervating the central trigeminal nuclei until E14.5.

Specimen 6Ac: embryonic day 14.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Section of brainstem at level of spinal trigeminal nuclei (Sp5).
Structure Level Pattern Image Note
TS22: trigeminal nerve Present Regionally restricted 6Ac Expression in trigeminal motoneurons.

Specimen 6Ad: embryonic day 14.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Section of brainstem at level of principle trigeminal nucleus (Pr5).
Structure Level Pattern Image Note
TS22: facial nerve Present Regionally restricted 6Ad Pioneer innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.
TS22: glossopharyngeal nerve Present Regionally restricted 6Ad Pioneer innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.
TS22: vagal nerve trunk Present Regionally restricted 6Ad Pioneer innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.

Specimen 6Ae: embryonic day 16.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Section of brainstem at level of principle trigeminal nucleus (Pr5)
Structure Level Pattern Image Note
TS24: trigeminal nerve Present Regionally restricted 6Ae Extensive trigeminal collateral projections.

Specimen 6Af: embryonic day 16.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Section of brainstem at level of spinal trigeminal nuclei (Sp5).
Structure Level Pattern Image Note
TS24: facial nerve Present Regionally restricted 6Af Innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.
TS24: glossopharyngeal nerve Present Regionally restricted 6Af Innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.
TS24: vagal nerve trunk Present Regionally restricted 6Af Innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.

Specimen 6Ag: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Section of brainstem at level of principle trigeminal nucleus (Pr5).
Structure Level Pattern Image Note
TS27: trigeminal nerve Present 6Ag Expression in trigeminal motorneurons.

Specimen 6Ah: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Section of brainstem at level of spinal trigeminal nuclei (Sp5).
Structure Level Pattern Image Note
TS27: facial nerve Present Regionally restricted 6Ah Innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.
TS27: glossopharyngeal nerve Present Regionally restricted 6Ah Innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.
TS27: vagal nerve trunk Present Regionally restricted 6Ah Innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.

Specimen 6Ai: postnatal day 7; Aviltm1(ALPP)Fawa/Avil+ (more )
Note: Section of brainstem at level of principle trigeminal nucleus (Pr5).
Structure Level Pattern Image Note
TS28: facial nerve Present Regionally restricted 6Ai Innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.
TS28: glossopharyngeal nerve Present Regionally restricted 6Ai Innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.
TS28: vagal nerve trunk Present Regionally restricted 6Ai Innervation of facial, glossopharyngeal and vagus nerves into the solitary tract nucleus.

Specimen 6Ba: embryonic day 12.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS20: mystacial pad Present Regionally restricted 6Ba
TS20: dorsal root ganglion Present 6Ba

Specimen 6Bb: embryonic day 14.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS22: spinal cord Present Regionally restricted 6Bb Proprioceptive Ia fibers and cutaneous mechanosensory axons innervation layer III/IV.
TS22: dorsal root ganglion Present Regionally restricted 6Bb

Specimen 6Bc: embryonic day 16.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS24: spinal cord Present Regionally restricted 6Bc Ia fibers form a branch to project fo medial part of spinal cord.
TS24: dorsal root ganglion Present 6Bc

Specimen 6Bd: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: spinal cord Present Regionally restricted 6Bd Mature pattern of dorsal root ganglion central projection is established.
TS27: dorsal root ganglion Present 6Bd

Specimen S2B: postnatal day 0; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS27: sympathetic ganglion Absent S2B

Specimen S3Aa: embryonic day 12.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS20: mystacial pad Present Regionally restricted S3Aa Expression in all sensory nerve endings.

Specimen S3Ba: embryonic day 12.5; Aviltm1(ALPP)Fawa/Avil+ (more )
Structure Level Pattern Image Note
TS20: forelimb Present Regionally restricted S3Ba Expression in all sensory nerve endings.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/14/2024
MGI 6.23
The Jackson Laboratory