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Gene Expression Data
Assay Details
Assay
Reference: J:39208 Sosa-Pineda B, et al., The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature. 1997 Mar 27;386(6623):399-402
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5756065
Gene symbol: Ins2
Gene name: insulin II
Antibody: anti-Insulin
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Assay notes: Both Ins1 (assay MGI:5756064) and Ins2 have been annotated.
Results
Specimen 2b: postnatal day 0; Pax4tm1Pgr/Pax4+ (more )
Note: Double labeled: brown - Ins1 and Ins2; blue - Pax4 reporter (assay MGI:5755864).
Structure Level Pattern Image Note
TS27: islets of Langerhans Present Regionally restricted 2b Expression is in beta cells.
Specimen 2e: postnatal day 0; Pax4tm1Pgr/Pax4tm1Pgr (more )
Note: Double labeled: brown - Ins1 and Ins2; blue - Pax4 reporter (assay MGI:5755864).
Structure Level Pattern Image Note
TS27: islets of Langerhans Present Single cells 2e Expression is in a few beta cells.
Specimen 3a: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: pancreas primordium dorsal bud Present 3a
Specimen 3d: embryonic day 10.5; Pax4tm1Pgr/Pax4tm1Pgr (more )
Structure Level Pattern Image Note
TS17: pancreas primordium dorsal bud Present 3d Expression in this mutant is the same as in wild-type.
Specimen not shown: embryonic day 13.5; Pax4tm1Pgr/Pax4tm1Pgr (more )
Structure Level Pattern Image Note
TS21: pancreas Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory