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Gene Expression Data
Assay Details
Assay
Reference: J:39208 Sosa-Pineda B, et al., The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature. 1997 Mar 27;386(6623):399-402
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5755864
Gene symbol: Pax4
Gene name: paired box 4
Reporter: lacZ
Direct Detection
Assay notes: Specimens were post-fixed with 4% paraformaldehyde.
Results
Specimen 2a: embryonic day 10.5; Pax4tm1Pgr/Pax4+ (more )
Structure Level Pattern Image Note
TS17: pancreas primordium dorsal bud Present 2a

Specimen 2b: postnatal day 0; Pax4tm1Pgr/Pax4+ (more )
Note: Double labeled: blue - Pax4 reporter; brown - Ins1 (assay MGI:5756064) and Ins2 (assay MGI:5756065).
Structure Level Pattern Image Note
TS27: islets of Langerhans Present Regionally restricted 2b Expression is in beta cells.

Specimen 2c: postnatal day 0; Pax4tm1Pgr/Pax4+ (more )
Note: Double labeled: blue - Pax4 reporter; brown - Gcg (assay MGI:5755996).
Structure Level Pattern Image Note
TS27: islets of Langerhans Present Regionally restricted 2c Expression is in beta cells.

Specimen 2d: embryonic day 10.5; Pax4tm1Pgr/Pax4tm1Pgr (more )
Structure Level Pattern Image Note
TS17: pancreas primordium dorsal bud Present 2d Expression in this mutant is the same as in wild-type.

Specimen 2e: postnatal day 0; Pax4tm1Pgr/Pax4tm1Pgr (more )
Note: Double labeled: blue - Pax4 reporter; brown - Ins1 (assay MGI:5756064) and Ins2 (assay MGI:5756065).
Structure Level Pattern Image Note
TS27: islets of Langerhans Absent 2e

Specimen 2f: postnatal day 0; Pax4tm1Pgr/Pax4tm1Pgr (more )
Note: Double labeled: blue - Pax4 reporter; brown - Gcg (assay MGI:5755996).
Structure Level Pattern Image Note
TS27: islets of Langerhans Absent 2f

Specimen not shown: embryonic day 11.0; Pax4tm1Pgr/Pax4+ (more )
Structure Level Pattern Image Note
TS18: pancreas primordium ventral bud Present

Specimen not shown E16.5: embryonic day 16.5; Pax4tm1Pgr/Pax4tm1Pgr (more )
Structure Level Pattern Image Note
TS24: pancreas Weak


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory