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Gene Expression Data
Assay Details
Assay
Reference: J:202865 Yang T, et al., Prickle1 stunts limb growth through alteration of cell polarity and gene expression. Dev Dyn. 2013 Nov;242(11):1293-306
Assay type: RNA in situ
MGI Accession ID: MGI:5751327
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 cDNA5
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 5A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forelimb digit 2 Present Regionally restricted 5A Expression in distal regions of digits 2-5.
TS20: forelimb digit 3 Present Regionally restricted 5A Expression in distal regions of digits 2-5.
TS20: forelimb digit 4 Present Regionally restricted 5A Expression in distal regions of digits 2-5.
TS20: forelimb digit 5 Present Regionally restricted 5A Expression in distal regions of digits 2-5.
TS20: forelimb digit mesenchyme Weak 5A Authors report low expression in developing digit rays.
Specimen 5B: embryonic day 12.5; Prickle1m2Ingm/Prickle1m2Ingm (more )
Structure Level Pattern Image Note
TS20: forelimb digit 2 Weak Regionally restricted 5B Greatly reduced expression in distal tip of digits 2, 4 and 5 compared with wild type.
TS20: forelimb digit 4 Weak Regionally restricted 5B Greatly reduced expression in distal tip of digits 2, 4 and 5 compared with wild type.
TS20: forelimb digit 5 Weak Regionally restricted 5B Greatly reduced expression in distal tip of digits 2, 4 and 5 compared with wild type.
TS20: forelimb digit 3 Weak Regionally restricted 5B Expression ablated in distal region of digit 3
Specimen 6E: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present 6E
TS19: handplate mesenchyme Present Regionally restricted 6E Expression in subridge mesenchyme.
Specimen 6F: embryonic day 11.5; Prickle1m2Ingm/Prickle1m2Ingm (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present 6F
TS19: handplate mesenchyme Present Regionally restricted 6F Reduced expression in an area of subridge mesenchyme.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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