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Gene Expression Data
Assay Details
Assay
Reference: J:35634 Marcinkiewicz M, et al., Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4922-6
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5707153
Gene symbol: Pcsk1
Gene name: proprotein convertase subtilisin/kexin type 1
Antibody: anti-PC1-CT
Detection system: Secondary antibody coupled to rhodamine
Results
Specimen 4A: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: adenohypophysis pars anterior Weak 4A Weak expression in both intermediate and anterior lobes.
TS24: adenohypophysis pars intermedia Weak Regionally restricted 4A In intermediate lobe melanotrophs, low levels of expression were detected at all developmental stages.

Specimen 4B: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: adenohypophysis pars anterior Weak 4B Expression in the anterior lobe did not change appreciably during the prenatal period.
TS27: adenohypophysis pars intermedia Weak Regionally restricted 4B In intermediate lobe melanotrophs, low levels of expression were detected at all developmental stages.

Specimen 4C: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: adenohypophysis pars anterior Weak 4C Expression increased substantially from P1 to P3 through adulthood.
TS27: adenohypophysis pars intermedia Weak Regionally restricted 4C In intermediate lobe melanotrophs, low levels of expression were detected at all developmental stages.

Specimen 4E: postnatal adult (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars anterior Present 4E Expression increased substantially from P1 to P3 through adulthood.
TS28: adenohypophysis pars intermedia Weak Regionally restricted 4E In intermediate lobe melanotrophs, low levels of expression were detected at all developmental stages.
TS28: neurohypophysis pars nervosa Strong Regionally restricted 4E During the interval P3 to adult, a large increase in expression in nerve endings of the posterior lobe.

Specimen 4F: postnatal adult (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars anterior Present Regionally restricted 4F Expression in a majority of corticotrophs.

Specimen 4H: postnatal adult (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars anterior Present Regionally restricted 4H Expression in some gonadotrophs.

Specimen Table 1 E11: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: future neurohypophysis Absent

Specimen Table 1 E12: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: adenohypophysis pars anterior Absent
TS20: adenohypophysis pars intermedia Absent

Specimen Table 1 E13: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: adenohypophysis pars anterior Absent
TS21: adenohypophysis pars intermedia Absent

Specimen Table 1 E14: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: adenohypophysis pars anterior Absent
TS22: adenohypophysis pars intermedia Absent

Specimen Table 1 E15: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: adenohypophysis pars anterior Absent
TS23: adenohypophysis pars intermedia Absent

Specimen Table 1 E16: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: adenohypophysis pars anterior Absent
TS24: adenohypophysis pars intermedia Absent

Specimen Table 1 E17: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: adenohypophysis pars intermedia Absent
TS25: adenohypophysis pars anterior Ambiguous

Specimen Table 1 E18: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: adenohypophysis pars intermedia Ambiguous
TS26: adenohypophysis pars anterior Trace

Specimen Table 1 E20: embryonic day 20.0 (more )
Structure Level Pattern Image Note
TS26: adenohypophysis pars anterior Trace
TS26: adenohypophysis pars intermedia Trace

Specimen Table 1 P1: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: adenohypophysis pars intermedia Trace
TS27: adenohypophysis pars anterior Weak

Specimen Table 1 P3: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: adenohypophysis pars anterior Weak
TS27: adenohypophysis pars intermedia Weak

Specimen Table 1 P5: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Weak
TS28: adenohypophysis pars anterior Present

Specimen Table 1 P7: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Weak
TS28: adenohypophysis pars anterior Present

Specimen Table 1 P9: postnatal day 9 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Weak
TS28: adenohypophysis pars anterior Present

Specimen Table 1 P11: postnatal day 11 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Weak
TS28: adenohypophysis pars anterior Present

Specimen Table 1 P14: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Weak
TS28: adenohypophysis pars anterior Strong

Specimen Table 1 Adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Weak
TS28: adenohypophysis pars anterior Very strong


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory