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Gene Expression Data
Assay Details
Assay
Reference: J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22
Assay type: RNA in situ
MGI Accession ID: MGI:5701407
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh cDNA2
Probe preparation: Antisense RNA
Results
Specimen 3A Control--left: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: node Present 3A Control E7.5
Specimen 3A Mutant--left: embryonic day 7.5; Lhx1tm1Bhr/Lhx1tm2.1Rob, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS11: node Absent 3A Lhx1 delta Epi E7.5
Specimen 3A Control--center: embryonic day 7.75 (more )
Structure Level Pattern Image Note
TS12: embryo Present Regionally restricted 3A Control E7.75 Expression is seen along the anterior midline.
Specimen 3A Mutant--center: embryonic day 7.75; Lhx1tm1Bhr/Lhx1tm2.1Rob, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS12: embryo Present Regionally restricted 3A Lhx1 delta Epi E7.75 Expression along the anterior midline is discontinuous and fails to extend anteriorly.
Specimen 3A Control--right: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: embryo Present Regionally restricted 3A Control E8.5 Expression is seen along the midline and includes a domain underlying the ventral forebrain.
Specimen 3A Mutant--right: embryonic day 8.5; Lhx1tm1Bhr/Lhx1tm2.1Rob, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: embryo Present Regionally restricted 3A Lhx1 delta Epi E8.5 Unlike in wild type, there is no domain of expression underlying the ventral forebrain; the anterior midline expression is severely disturbed.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory