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Gene Expression Data
Assay Details
Assay
Reference: J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22
Assay type: RNA in situ
MGI Accession ID: MGI:5701386
Gene symbol: Foxa2
Gene name: forkhead box A2
Probe: Foxa2 probe10
Probe preparation: Antisense RNA
Results
Specimen 2C Control--left: embryonic day 7.75 (more )
Structure Level Pattern Image Note
TS11: mesendoderm Present Regionally restricted 2C Control E7.75 Expression is seen in the anterior midline mesendoderm and its derivatives.
TS11: node Present 2C Control E7.75 Expression is seen in the node and its derivatives.
Specimen 2C Mutant--left: embryonic day 7.75; Lhx1tm1Bhr/Lhx1tm2.1Rob, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS11: mesendoderm Present Regionally restricted 2C Lhx1 delta Epi E7.75 In the mutant expression is markedly reduced in the anterior mesendoderm and emerging midline.
TS11: node Present 2C Lhx1 delta Epi E7.75 In the mutant robust expression is retained in the node progenitors at the tip of the primitive streak.
Specimen 2C Control--right: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: embryo Present Regionally restricted 2C Control E8.5 Expression is seen at the midline.
Specimen 2C Mutant--right: embryonic day 8.5; Lhx1tm1Bhr/Lhx1tm2.1Rob, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: embryo Present Regionally restricted 2C Lhx1 delta Epi E8.5 The mutants display reduced expression at the midline; there is no expression in the anterior midline underlying the forebrain/midbrain.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory