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Gene Expression Data
Assay Details
Assay
Reference: J:155096 Han J, et al., Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development. 2009 Dec;136(24):4225-33
Assay type: RNA in situ
MGI Accession ID: MGI:5691599
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh probe108
Probe preparation: Antisense labelled with dinitrophenyl RNA
Results
Specimen 1G: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 1G Expression only on oral side.

Specimen 2G: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: palatal shelf Present 2G

Specimen 2H: embryonic day 12.5; Dlx5tm1Jlr/Dlx5tm1Jlr (more )
Structure Level Pattern Image Note
TS20: palatal shelf Present 2H

Specimen 2I: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 2I Expression in palatal epithelium restricted to oral side of palatal epithelium.
TS21: palatal rugae Present 2I Expression limited to defined stripes that correspond to developing rugae

Specimen 2J: embryonic day 13.5; Dlx5tm1Jlr/Dlx5tm1Jlr (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 2J Authors describe expansion of expression into the medial edge epithelium (MEE) and nasal side of the palatal epithelium, with persistence of oral side expression.

Specimen 2K: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present 2K

Specimen 2L: embryonic day 13.5; Dlx5tm1Jlr/Dlx5tm1Jlr (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 2L Authors describe expansion on expression into the medial edge epithelium (MEE) and nasal side of the palatal epithelium.

Specimen 2M: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: palatal shelf epithelium Present 2M

Specimen 2N: embryonic day 14.5; Dlx5tm1Jlr/Dlx5tm1Jlr (more )
Structure Level Pattern Image Note
TS22: palatal shelf epithelium Present 2N

Specimen 2O: embryonic day 14.5; Msx1tm1Rilm/Msx1tm1Rilm (more )
Structure Level Pattern Image Note
TS22: palatal shelf epithelium Present Regionally restricted 2O Diminished expression in anterior part of oral palatal epithelium. No expression in epithelial cells covering the palatal shelf.

Specimen 4A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 4A
TS21: palatal rugae Present 4A Expression restricted to the epithelial thickening, the developing rugae.

Specimen 4B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 4B
TS21: palatal rugae Present 4B Expression restricted to the epithelial thickening, the developing rugae.

Specimen 7A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 7A
TS21: palatal rugae Present 7A Expression restricted to the epithelial thickening, the developing rugae.

Specimen 7B: embryonic day 13.5; Msx1tm1Rilm/Msx1tm1Rilm (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Absent 7B

Specimen 7C: embryonic day 13.5; Dlx5tm1Jlr/Dlx5tm1Jlr (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 7C Expanded expression in the palatal shelf epithelium.

Specimen 7D: embryonic day 13.5; Dlx5tm1Jlr/Dlx5tm1Jlr, Msx1tm1Rilm/Msx1tm1Rilm (more )
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Present Regionally restricted 7D Expansion of expression in palatal epithelium similar to that seen in Msx1-/- mutants.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory