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Gene Expression Data
Assay Details
Assay
Reference: J:217599 Gonzalez-Lazaro M, et al., Two new targeted alleles for the comprehensive analysis of Meis1 functions in the mouse. Genesis. 2014 Dec;52(12):967-75
Assay type: Recombinase reporter
MGI Accession ID: MGI:5689674
Gene symbol: Meis1
Gene name: Meis homeobox 1
Reporter: lacZ
Direct Detection
Assay notes: Induction was achieved by tamoxifen (Sigma-Aldrich; 20 mg/ml diluted in corn oil) treatment of pregnant dams by oral gavage with either 3 mg at E8.25 or 4 mg at E9.5. Increasing tamoxifen dose or injecting at earlier (E6.5-E7.5) and later stages (E10.5) does not change observations.
Results
Specimen 4d: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Meis1tm3.1(cre/ERT2)Mtor/Meis1+ (more )
Note: Conditional mutant. Treated with 3 mg tamoxifen at E8.25
Structure Level Pattern Image Note
TS21: forelimb Present 4d
TS21: embryo Present 4d Recombinase reporter activity is detected in the pericardial region.
Specimen 4e: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Meis1tm3.1(cre/ERT2)Mtor/Meis1+ (more )
Note: Conditional mutant. Treated with 3 mg tamoxifen at E8.25
Structure Level Pattern Image Note
TS21: forelimb Present 4e Recombinase reporter staining is detected along the proximo-distal limb axis.
Specimen 4f: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Meis1tm3.1(cre/ERT2)Mtor/Meis1+ (more )
Note: Conditional mutant. Treated with 4 mg tamoxifen at E9.5
Structure Level Pattern Image Note
TS21: embryo Present 4f
Specimen 4g: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Meis1tm3.1(cre/ERT2)Mtor/Meis1+ (more )
Note: Conditional mutant. Treated with 4 mg tamoxifen at E9.5
Structure Level Pattern Image Note
TS21: forelimb Present 4g Recombinase reporter staining is detected in the proximal limb.
Specimen 4h: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Meis1tm3.1(cre/ERT2)Mtor/Meis1+ (more )
Note: Conditional mutant. Treated with 4 mg tamoxifen at E9.5
Structure Level Pattern Image Note
TS21: face Present 4h Recombinase reporter staining is detected in the facial mesenchyme and fronto-nasal mesenchyme. However, staining is not observed in the majority of the 1rst branchial arch-derived tissues.
Specimen 4i: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Meis1tm3.1(cre/ERT2)Mtor/Meis1+ (more )
Note: Conditional mutant. Treated with 4 mg tamoxifen at E9.5
Structure Level Pattern Image Note
TS21: eye Present 4i
TS21: lens Present 4i
TS21: face Present 4i Recombinase reporter staining is detected in the periocular region ectoderm.
Specimen 4l: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Meis1tm3.1(cre/ERT2)Mtor/Meis1+ (more )
Note: Conditional mutant. Treated with 4 mg tamoxifen at E9.5
Structure Level Pattern Image Note
TS21: retina Present 4l
Specimen 4m: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Meis1tm3.1(cre/ERT2)Mtor/Meis1+ (more )
Note: Conditional mutant. Treated with 4 mg tamoxifen at E9.5
Structure Level Pattern Image Note
TS21: lens Present 4m
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
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