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Gene Expression Data
Assay Details
Assay
Reference: J:223515 Kunze S, et al., New mutation in the mouse xpd/ercc2 gene leads to recessive cataracts. PLoS One. 2015;10(5):e0125304
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5689413
Gene symbol: H2ax
Gene name: H2A.X variant histone
Antibody: anti-phospho-histone H2A.X (20E3) (CST;#9718)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen C3H E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lens Present Regionally restricted 7_C3H E17.5 Expression is present at the anterior center of the lens.
TS25: lens fiber Present Regionally restricted 7_C3H E17.5 Expression is present at the anterior center of the lens.

Specimen C3H P1: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: lens Present Regionally restricted 7_C3H P1 Expession is present in the innermost secondary fiber cells.
TS27: lens fiber Present Regionally restricted 7_C3H P1 Expession is present in the innermost secondary fiber cells.

Specimen C3H P7: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: lens Present Regionally restricted 7_C3H P7 Expression is found in a ring, at the transition to the organelle-free zone.
TS28: lens fiber Present Regionally restricted 7_C3H P7 Expression is found in a ring, at the transition to the organelle-free zone.

Specimen C3H P14: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: lens Present Regionally restricted 7_C3H P14 Expression is found in a ring, at the transition to the organelle-free zone.
TS28: lens fiber Present Regionally restricted 7_C3H P14 Expression is found in a ring, at the transition to the organelle-free zone.

Specimen het E17.5: embryonic day 17.5; Ercc2Mhdarco15/Ercc2+ (more )
Structure Level Pattern Image Note
TS25: lens Present Regionally restricted 7_het E17.5 Expression is present at the anterior center of the lens.
TS25: lens fiber Present Regionally restricted 7_het E17.5 Expression is present at the anterior center of the lens.

Specimen het P1: postnatal day 1; Ercc2Mhdarco15/Ercc2+ (more )
Structure Level Pattern Image Note
TS27: lens Present Regionally restricted 7_het P1 Expession is present in the innermost secondary fiber cells.
TS27: lens fiber Present Regionally restricted 7_het P1 Expession is present in the innermost secondary fiber cells.

Specimen het P7: postnatal day 7; Ercc2Mhdarco15/Ercc2+ (more )
Structure Level Pattern Image Note
TS28: lens Present Regionally restricted 7_het P7 Expression is found in a ring, at the transition to the organelle-free zone.
TS28: lens fiber Present Regionally restricted 7_het P7 Expression is found in a ring, at the transition to the organelle-free zone.

Specimen het P14: postnatal day 14; Ercc2Mhdarco15/Ercc2+ (more )
Structure Level Pattern Image Note
TS28: lens Present Regionally restricted 7_het P14 Expression is found in a ring, at the transition to the organelle-free zone.
TS28: lens fiber Present Regionally restricted 7_het P14 Expression is found in a ring, at the transition to the organelle-free zone.

Specimen hom E17.5: embryonic day 17.5; Ercc2Mhdarco15/Ercc2Mhdarco15 (more )
Structure Level Pattern Image Note
TS25: lens Present Regionally restricted 7_hom E17.5 Expression is present at the anterior center of the lens.
TS25: lens fiber Present Regionally restricted 7_hom E17.5 Expression is present at the anterior center of the lens.

Specimen hom P1: postnatal day 1; Ercc2Mhdarco15/Ercc2Mhdarco15 (more )
Structure Level Pattern Image Note
TS27: lens Present Regionally restricted 7_hom P1 Expession is present in the innermost secondary fiber cells.
TS27: lens fiber Present Regionally restricted 7_hom P1 Expession is present in the innermost secondary fiber cells.

Specimen hom P7: postnatal day 7; Ercc2Mhdarco15/Ercc2Mhdarco15 (more )
Structure Level Pattern Image Note
TS28: lens Present Regionally restricted 7_hom P7 Expression is found in a ring, at the transition to the organelle-free zone. In the mutant this ring appears earlier and is broader than in wild type.
TS28: lens fiber Present Regionally restricted 7_hom P7 Expression is found in a ring, at the transition to the organelle-free zone. In the mutant this ring appears earlier and is broader than in wild type.

Specimen hom P14: postnatal day 14; Ercc2Mhdarco15/Ercc2Mhdarco15 (more )
Structure Level Pattern Image Note
TS28: lens Present Regionally restricted 7_hom P14 Expression is found in a ring, at the transition to the organelle-free zone. In the mutant this ring appears earlier and is broader than in wild type.
TS28: lens fiber Present Regionally restricted 7_hom P14 Expression is found in a ring, at the transition to the organelle-free zone. In the mutant this ring appears earlier and is broader than in wild type.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory