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Gene Expression Data
Assay Details
Assay
Reference: J:83738 Pauley S, et al., Expression and function of FGF10 in mammalian inner ear development. Dev Dyn. 2003 Jun;227(2):203-15
Assay type: RNA in situ
MGI Accession ID: MGI:5661339
Gene symbol: Fgf10
Gene name: fibroblast growth factor 10
Probe: Fgf10 cDNA10
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 1A Expression in the entire ventral otocyst, concentrated in the lower half of the otocyst
TS15: inner ear Present Regionally restricted 1A Expression did not extend to the presumptive endolymphatic duct.

Specimen 1B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: inner ear vestibular component Present Regionally restricted 1B Strong expression in 3 distinct patches identified as future epithelia for the canal crista. Strong expression in anterior part of cochlea.
TS19: acoustic ganglion Present Regionally restricted 1B Expression in delaminating sensory neurons of cochlear and vestibular ganglia.

Specimen 1C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: inner ear vestibular component Present Regionally restricted 1C Strong expression in three distince patches identified as future epithelia for the three canal crista. Less prominent expression in the cochlea.

Specimen 1D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: inner ear Present Regionally restricted 1D Strong expression on anterior pole of otocyst Anterior patch of expression includes forming sensory neurons. Less extensive area of expression at the posterior pole of the otocyst.
TS17: acoustic ganglion Present Regionally restricted 1D Expression in delaminating cells of the forming cochleovestibular ganglion.

Specimen 1E: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: inner ear vestibular component Present Regionally restricted 1E Strong expression in three distince patches identified as future epithelia for the three canal crista. Less prominent expression in the utricle.

Specimen 1F: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: inner ear vestibular component Present Regionally restricted 1F Strong expression in all three crista anlagen. Expression is throughout the columnar epithelium of the otocyst, but most concentrated in the ventricular layer.

Specimen 2A: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: crista ampullaris Present Regionally restricted 2A Asymmetric distribution of expression in sensory epithelium of posterior canal cristae. Crista organs retained strong expression, with only a limited indication of a gradient falling off toward the abneural side.

Specimen 2B: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: utricle epithelium Present Regionally restricted 2B Asymmetric distribution of expression in sensory epithelium of utricle. Higher concentration near theneural side, falling off toward the abneural side.

Specimen 2C: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cochlea Present Regionally restricted 2C Asymmetric expression increases through greater epithelial ridge to become strongest near row of inner hair cells. Strongest expression in greater epithelial ridge. No detectable expression in Claudius cells or cochlear lateral wall.
TS27: organ of Corti Present Regionally restricted 2C Strong expression in the spiral sensory neuron. Only faintly expressed around outer hair cells.

Specimen 2D: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cochlea Present Regionally restricted 2D Within the greater epithelial ridge, continusous increase in expression, highest at region adjacent to inner hair cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory