Thbs1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:91885 Saika S, et al., Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation. Exp Eye Res. 2004 Aug;79(2):147-56
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:5621186
Gene symbol:	Thbs1
Gene name:	thrombospondin 1

Antibody:	Anti-TSP1
Detection system:	Secondary antibody coupled to fluorescein

Results

Specimen 5A: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: lens epithelium	Weak		5A

Specimen 6A: embryonic day 11.5 (more

)

Structure	Level	Pattern	Image	Note
TS19: lens vesicle posterior epithelium	Present		6A
TS19: hyaloid cavity	Present		6A	Cells in the vitreous cavity were labeled.

Specimen not shown: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: lens vesicle posterior epithelium	Present

Specimen 6B,C: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: lens fiber	Present		6C , 6B
TS21: lens anterior epithelium	Present		6B , 6C

Specimen 6D: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: lens anterior epithelium	Present		6D
TS23: lens fiber	Present		6D

Specimen 6E,F: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: lens anterior epithelium	Present		6F , 6E
TS24: lens fiber	Present	Regionally restricted	6F , 6E	The body of elongated fibers were negative for expression. Only the anterior part of the fiber just beneath the anterior epithelium was positively stained.

Specimen 6G,H: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: lens anterior epithelium	Present		6H , 6G
TS26: lens equatorial epithelium	Weak		6G , 6H
TS26: lens fiber	Trace	Regionally restricted	6G , 6H	The majority of fibers were negative. Elongated fibers were negative, except for minor staining between each early fibers.

Specimen 6I: postnatal day 1 (more

)

Structure	Level	Pattern	Image	Note
TS27: lens anterior epithelium	Present		6I
TS27: lens fiber	Trace	Regionally restricted	6I	Expression is faded in early differentiating fibers.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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