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Gene Expression Data
Assay Details
Assay
Reference: J:135300 Babbs C, et al., Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Mech Dev. 2008 May-Jun;125(5-6):517-26
Assay type: RNA in situ
MGI Accession ID: MGI:5616750
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 probe51
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 4 wt: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Present Regionally restricted 4_Bmp4 wt Expression is in the progress zone.
TS17: forelimb bud apical ectodermal ridge Absent 4_Bmp4 wt
Specimen 4 Dbf/+: embryonic day 10.5; Dbf/Dbf+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Present Regionally restricted 4_Bmp4 Dbf/+ Expression in the progress zone was downregulated but up-regulated proximally in this mutant.
TS17: forelimb bud apical ectodermal ridge Absent 4_Bmp4 Dbf/+
Specimen 4 Shh-/-: embryonic day 10.5; Shhtm1Chg/Shhtm1Chg (more )
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Present Regionally restricted 4_Bmp4 Shh-/-
Specimen 4 Shh-/-;Dbf/+: embryonic day 10.5; Dbf/Dbf+, Shhtm1Chg/Shhtm1Chg (more )
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Weak Regionally restricted 4_Bmp4 Shh-/-;Dbf/+ Expression is in the progress zone.
TS17: forelimb bud apical ectodermal ridge Present 4_Bmp4 Shh-/-;Dbf/+
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory