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Gene Expression Data
Assay Details
Assay
Reference: J:177409 Young T, et al., Mutated in colorectal cancer (Mcc), a candidate tumor suppressor, is dynamically expressed during mouse embryogenesis. Dev Dyn. 2011 Sep;240(9):2166-74
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5587969
Gene symbol: Mcc
Gene name: mutated in colorectal cancers
Reporter: lacZ
Direct Detection
Results
Specimen not shown: embryonic day 6.5; MccGt(D062B07)Wrst/Mcc+ (more )
Structure Level Pattern Image Note
TS9: embryo Trace
Specimen 4A left: embryonic day 7.5; MccGt(D062B07)Wrst/Mcc+ (more )
Structure Level Pattern Image Note
TS11: primitive streak Present 4A inset left
TS11: embryo Present Regionally restricted 4A inset left Expression is in the posterior epiblast.
Specimen 4A right: embryonic day 7.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS11: primitive streak Present 4A inset right
TS11: embryo Present Regionally restricted 4A inset right Expression is in the posterior epiblast and in cells ingressing through and emerging from the primitive streak.
TS11: extraembryonic endoderm Absent 4A inset right
TS11: embryo mesoderm Absent 4A inset right Absent in lateral migrating mesoderm.
Specimen 4A E8.5: embryonic day 8.5; MccGt(D062B07)Wrst/Mcc+ (more )
Structure Level Pattern Image Note
TS13: heart Strong 4A E8.5
TS13: lateral plate mesoderm Strong 4A E8.5
TS13: notochord Strong 4A E8.5
TS13: trunk unsegmented mesenchyme Strong 4A E8.5
TS13: somite Strong Regionally restricted 4A E8.5 Expression is in newly formed somites.
Specimen 4A E9.5: embryonic day 9.5; MccGt(D062B07)Wrst/Mcc+ (more )
Structure Level Pattern Image Note
TS15: branchial arch Present 4A E9.5
TS15: somite Present 4A E9.5
TS15: tail Present 4A E9.5
Specimen 4A E10.5: embryonic day 10.5; MccGt(D062B07)Wrst/Mcc+ (more )
Structure Level Pattern Image Note
TS17: dermomyotome Present 4A E10.5
TS17: head mesenchyme Present 4A E10.5
TS17: midgut mesenchyme Present 4A E10.5
TS17: neural tube Present 4A E10.5
Specimen 4C: embryonic day 8.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS13: future spinal cord neural plate Strong 4C
TS13: hindgut diverticulum endoderm Strong 4C
TS13: head mesenchyme Present 4C
TS13: lateral plate mesoderm Present 4C
TS13: notochord Present 4C
TS13: somite Present 4C
TS13: gut endoderm Present Graded 4C Expression declines from posterior to anterior.
TS13: foregut diverticulum endoderm Weak 4C
TS13: cardiac muscle tissue Present 4C Expression is in trabeculated myocardium.
Specimen 4Ci: embryonic day 8.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS13: future spinal cord neural plate Strong 4Ci
TS13: hindgut diverticulum endoderm Present 4Ci
TS13: lateral plate mesoderm Present 4Ci
TS13: notochord Present 4Ci
TS13: future hindbrain Present Regionally restricted 4Ci Expression is in a narrow patch.
TS13: cardiac muscle tissue Present Regionally restricted 4Ci Expression is in trabeculated myocardium.
Specimen 4Cii: embryonic day 8.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS13: future spinal cord neural plate Strong 4Cii
TS13: lateral plate mesoderm Present 4Cii
TS13: midgut Present 4Cii
TS13: somite Present 4Cii
TS13: foregut diverticulum endoderm Weak 4Cii
Specimen 4Ciii: embryonic day 8.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS13: future spinal cord neural plate Strong 4Ciii
TS13: lateral plate mesoderm Present 4Ciii
TS13: somite Present 4Ciii
Specimen 4D: embryonic day 9.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS15: head mesenchyme Present 4D
Specimen 4Di: embryonic day 9.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS15: future brain Present Regionally restricted 4Di Expression is in cell populations bordering the fourth ventricle.
TS15: branchial arch Present 4Di
TS15: head mesenchyme Present 4Di
TS15: otocyst Present 4Di
Specimen 4Dii: embryonic day 9.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS15: branchial arch Present 4Dii
TS15: facio-acoustic preganglion complex Present 4Dii
TS15: head mesenchyme Present 4Dii
TS15: otocyst Present 4Dii
Specimen 4Diii left: embryonic day 9.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS15: tail neural plate Present 4Diii left Expression is in the open neural plate.
TS15: neural tube Weak Regionally restricted 4Diii left Expression is in the open neural plate and is downregulated in the closed neural tube.
TS15: midgut epithelium Present 4Diii left
TS15: notochord Present 4Diii left
Specimen 4Diii right: embryonic day 9.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS15: dermomyotome Present Regionally restricted 4Diii right Expression is in dermomyotome-derived premuscle tissue.
TS15: cardiac muscle tissue Present Regionally restricted 4Diii right Expression is in trabeculated myocardium.
TS15: branchial arch Present 4Diii right
Specimen 4Div: embryonic day 9.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS15: midgut epithelium Present 4Div
TS15: notochord Present 4Div
TS15: somite Present 4Div
TS15: neural tube Weak Regionally restricted 4Div Expression is in the open neural plate and is downregulated in the closed neural tube.
Specimen 4Dv: embryonic day 9.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS15: somite Present 4Dv
TS15: neural tube Weak Regionally restricted 4Dv Expression is in the open neural plate and is downregulated in the closed neural tube.
Specimen 4E: embryonic day 10.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS17: head mesenchyme Present 4E
TS17: neural tube lateral wall Present Regionally restricted 4E Expression is in two parallel tracts of ventral motor neurons.
Specimen 4Ei: embryonic day 10.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS17: head mesenchyme Present 4Ei
Specimen 4Eii: embryonic day 10.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS17: cardiac muscle tissue Present Regionally restricted 4Eii Expression is in trabeculated myocardium.
TS17: dermomyotome Present Regionally restricted 4Eii Expression is in dermomyotome-derived premuscle tissue.
TS17: midgut mesenchyme Present 4Eii
Specimen 4Eiii: embryonic day 10.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS17: dermomyotome Present Regionally restricted 4Eiii Expression is in dermomyotome-derived premuscle tissue.
TS17: midgut mesenchyme Present 4Eiii
Specimen 4Eiv: embryonic day 10.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS17: dermomyotome Present Regionally restricted 4Eiv Expression is in dermomyotome-derived premuscle tissue.
TS17: neural tube Present Regionally restricted 4Eiv Expression is in two parallel tracts of ventral motor neurons.
Specimen 4Evi: embryonic day 10.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS17: dermomyotome Present Regionally restricted 4Evi Expression is in dermomyotome-derived premuscle tissue.
TS17: neural tube Present Regionally restricted 4Evi Expression is in two parallel tracts of ventral motor neurons.
Specimen 5A: embryonic day 11.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS19: body wall mesenchyme Present 5A
TS19: central nervous system ganglion Present 5A
TS19: head mesenchyme Present 5A
Specimen 5Ai: embryonic day 11.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS19: central nervous system ganglion Present 5Ai
TS19: dorsal root ganglion Present 5Ai
TS19: head mesenchyme Present 5Ai
TS19: neural retinal epithelium Present 5Ai
TS19: perioptic mesenchyme Present 5Ai
TS19: sympathetic ganglion Present 5Ai
Specimen 5Aii: embryonic day 11.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS19: body wall mesenchyme Present 5Aii
TS19: central nervous system ganglion Present 5Aii
TS19: dorsal root ganglion Present 5Aii
TS19: sympathetic ganglion Present 5Aii
TS19: dermomyotome Present Regionally restricted 5Aii Expression is in dorsolateral myotome-derived premuscsle masses.
Specimen 5Aiii: embryonic day 11.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS19: body wall mesenchyme Present 5Aiii
TS19: cardiac muscle tissue Present 5Aiii
TS19: central nervous system ganglion Present 5Aiii
TS19: dorsal root ganglion Present 5Aiii
TS19: midgut Present 5Aiii
TS19: dermomyotome Present Regionally restricted 5Aiii Expression is in dorsolateral myotome-derived premuscsle masses.
TS19: hindgut Weak 5Aiii
Specimen 5Aiv: embryonic day 11.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS19: dorsal root ganglion Present 5Aiv
TS19: neural tube basal columns Present 5Aiv
TS19: dermomyotome Present Regionally restricted 5Aiv Expression is in dorsolateral myotome-derived premuscsle masses.
Specimen 5B: embryonic day 12.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS20: basal columns Present 5B
TS20: dorsal root ganglion Present 5B
TS20: head mesenchyme Present 5B
Specimen 5Bi: embryonic day 12.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS20: central nervous system ganglion Present 5Bi
TS20: neural retinal epithelium Present 5Bi
TS20: perioptic mesenchyme Present 5Bi
TS20: skeletal muscle Present 5Bi
Specimen 5Bii: embryonic day 12.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS20: body wall mesenchyme Present 5Bii
TS20: dorsal root ganglion Present 5Bii
TS20: nasal septum Present 5Bii
TS20: skeletal muscle Present 5Bii
Specimen 5Biii: embryonic day 12.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS20: basal columns Present 5Biii
TS20: body wall mesenchyme Present 5Biii
TS20: midgut Present 5Biii
TS20: skeletal muscle Present 5Biii
TS20: spinal ganglion Present 5Biii
Specimen 5Biv: embryonic day 12.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS20: basal columns Present 5Biv
TS20: dorsal root ganglion Present 5Biv
TS20: skeletal muscle Present 5Biv
Specimen 5Bv: embryonic day 12.5; MccGt(D062B07)Wrst/Mcc+ (more )
Note: Vibratome section.
Structure Level Pattern Image Note
TS20: basal columns Present 5Bv
TS20: dorsal root ganglion Present 5Bv
Specimen 6A: postnatal adult; MccGt(D062B07)Wrst/MccGt(D062B07)Wrst (more )
Structure Level Pattern Image Note
TS28: intestinal villus Present 6A
TS28: small intestine crypt of lieberkuhn Present 6A
TS28: small intestine smooth muscle Present Scattered 6A
Specimen 6B: postnatal adult; MccGt(D062B07)Wrst/MccGt(D062B07)Wrst (more )
Structure Level Pattern Image Note
TS28: colon epithelium Present 6B Expression is clustered at the crypt bottom including goblet cells and colonocytes.
TS28: colon muscularis Present Scattered 6B
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory