About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
Assay type: RNA in situ
MGI Accession ID: MGI:5541837
Gene symbol: Pcsk9
Gene name: proprotein convertase subtilisin/kexin type 9
Probe: RIKEN clone A730053K11 subclone 1
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen GUDMAP:8962: embryonic day 15.5 (more )
Note: Labeling was visualized using BM purple. The low level expression control (Shh) showed only very weak expression. Thus, genes with a low level expression may not be detected. Some background signal was detected in the nephrogenic zone with Wnt7b.
Structure Level Pattern Image Note
TS23: urinary system Present Regionally restricted GUDMAP:8962
TS23: metanephros Present Regionally restricted GUDMAP:8962
TS23: renal cortex Present Regionally restricted GUDMAP:8962
TS23: renal vesicle Present Regionally restricted GUDMAP:8962 distal expression; weak expression only; appears restricted to the distal end of the renal vesicle
TS23: comma-shaped body Present Regionally restricted GUDMAP:8962 distal expression; strong regional expression in the upper limb of comma-shaped body
TS23: upper limb of comma-shaped body Present GUDMAP:8962
TS23: s-shaped body Present Regionally restricted GUDMAP:8962 strong restricted expression in the medial segment of S-shaped body
TS23: medial segment of s-shaped body Present GUDMAP:8962
TS23: cortical renal tubule Present Regionally restricted GUDMAP:8962 distal expression; obvious strong expression in the distal tubules and may extend into anlage of loop of Henle
TS23: cortical early distal tubule Present GUDMAP:8962 strong expression in capillary loop and maturing nephrons; seen adjacent to the immature loop of Henle of maturing nephrons adjacent to the medulla
TS23: nephrogenic zone Absent GUDMAP:8962
TS23: nephrogenic interstitium Absent GUDMAP:8962
TS23: cap mesenchyme Absent GUDMAP:8962
TS23: pretubular aggregate Absent GUDMAP:8962
TS23: ureteric tip Absent GUDMAP:8962
TS23: ureteric tree terminal branch excluding tip itself Absent GUDMAP:8962
TS23: lower limb of comma-shaped body Absent GUDMAP:8962
TS23: renal connecting tubule of s-shaped body Absent GUDMAP:8962
TS23: distal segment of s-shaped body Absent GUDMAP:8962
TS23: proximal segment of s-shaped body Absent GUDMAP:8962
TS23: visceral epithelium of s-shaped body Absent GUDMAP:8962
TS23: parietal epithelium of s-shaped body Absent GUDMAP:8962
TS23: capillary loop renal corpuscle Absent GUDMAP:8962
TS23: visceral epithelium of capillary loop renal corpuscle Absent GUDMAP:8962
TS23: parietal epithelium of capillary loop renal corpuscle Absent GUDMAP:8962
TS23: presumptive mesangium of capillary loop renal corpuscle Absent GUDMAP:8962
TS23: presumptive endothelium of capillary loop renal corpuscle Absent GUDMAP:8962
TS23: associated interstitium of capillary loop renal corpuscle Absent GUDMAP:8962
TS23: maturing renal corpuscle Absent GUDMAP:8962
TS23: maturing glomerular tuft Absent GUDMAP:8962
TS23: glomerular capillary system of maturing glomerular tuft Absent GUDMAP:8962
TS23: glomerular basement membrane of maturing renal corpuscle Absent GUDMAP:8962
TS23: glomerular mesangium of maturing glomerular tuft Absent GUDMAP:8962
TS23: visceral epithelium of maturing renal corpuscle Absent GUDMAP:8962
TS23: Bowman's capsule of maturing renal corpuscle Absent GUDMAP:8962
TS23: parietal epithelium of maturing renal corpuscle Absent GUDMAP:8962
TS23: glomerular mesangium of maturing renal corpuscle Absent GUDMAP:8962
TS23: juxtaglomerular arteriole Absent GUDMAP:8962
TS23: renal connecting tubule Absent GUDMAP:8962
TS23: cortical collecting duct Absent GUDMAP:8962
TS23: renal cortical interstitium Absent GUDMAP:8962
TS23: renal cortical vasculature Absent GUDMAP:8962
TS23: renal cortical arterial system Absent GUDMAP:8962
TS23: renal cortical venous system Absent GUDMAP:8962
TS23: renal cortical capillary Absent GUDMAP:8962
TS23: ureter Absent GUDMAP:8962
TS23: renal medulla Absent GUDMAP:8962
TS23: immature loop of Henle Absent GUDMAP:8962
TS23: straight limb of immature loop of Henle Absent GUDMAP:8962
TS23: bend of immature loop of Henle Absent GUDMAP:8962
TS23: renal medullary interstitium Absent GUDMAP:8962
TS23: renal medullary vasculature Absent GUDMAP:8962
TS23: renal medullary arterial system Absent GUDMAP:8962
TS23: renal medullary venous system Absent GUDMAP:8962
TS23: renal medullary capillary Absent GUDMAP:8962
TS23: medullary collecting duct Absent GUDMAP:8962
TS23: renal calyx Absent GUDMAP:8962
TS23: renal pelvis Absent GUDMAP:8962
TS23: pelvic urothelial lining Absent GUDMAP:8962
TS23: pelvic smooth muscle Absent GUDMAP:8962
TS23: perihilar interstitium Absent GUDMAP:8962
TS23: cortical early proximal tubule Ambiguous GUDMAP:8962 absent from capillary loop nephrons; uncertain expression in maturing nephrons due to difficulty in identifying tubule subtypes
TS23: anlage of loop of Henle of cortical renal tubule Ambiguous GUDMAP:8962 strong expression in early distal tubules of capillary loop nephrons which may include a portion of the anlage of loop of Henle
Specimen GUDMAP:8963: postnatal adult (more )
Note: This animal was sexually mature. Visualized using BM purple. The low level expression control (Shh) showed only very weak expression. Thus genes with a low level expression may not be detected. Some background was noted in the nephrogenic zone with Wnt7b.
Structure Level Pattern Image Note
TS28: metanephros Absent GUDMAP:8963
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory