Umod RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
Assay type:	RNA in situ
MGI Accession ID:	MGI:5540919
Gene symbol:	Umod
Gene name:	uromodulin

Probe:	RIKEN clone D630003D16 subclone
Probe preparation:	Antisense labelled with digoxigenin RNA
Visualized with:	Alkaline phosphatase

Results

GUDMAP:9104 ©

Specimen GUDMAP:9104: embryonic day 15.5 (more

)
Note: Labeling was visualized using BM purple.

Structure	Level	Pattern	Image	Note
TS23: urinary system	Present	Regionally restricted	GUDMAP:9104
TS23: metanephros	Present	Regionally restricted	GUDMAP:9104
TS23: renal medulla	Present	Regionally restricted	GUDMAP:9104
TS23: immature loop of Henle	Present		GUDMAP:9104	specific expression in immature loop of Henle; absent from anlage of loop of Henle uromodulin syn: Tamm horsfall glyocoprotein is a well known marker of distal straight tubule of outer medulla and cortex and distal convoluted tubule of cortex
TS23: maturing nephron	Present	Regionally restricted	GUDMAP:9104
TS23: late tubule	Present		GUDMAP:9104
TS23: renal capsule	Absent		GUDMAP:9104
TS23: nephrogenic zone	Absent		GUDMAP:9104
TS23: nephrogenic interstitium	Absent		GUDMAP:9104
TS23: cap mesenchyme	Absent		GUDMAP:9104
TS23: pretubular aggregate	Absent		GUDMAP:9104
TS23: ureteric tip	Absent		GUDMAP:9104
TS23: ureteric tree terminal branch excluding tip itself	Absent		GUDMAP:9104
TS23: renal cortex	Absent		GUDMAP:9104
TS23: renal vesicle	Absent		GUDMAP:9104
TS23: comma-shaped body	Absent		GUDMAP:9104
TS23: upper limb of comma-shaped body	Absent		GUDMAP:9104
TS23: lower limb of comma-shaped body	Absent		GUDMAP:9104
TS23: s-shaped body	Absent		GUDMAP:9104
TS23: renal connecting tubule of s-shaped body	Absent		GUDMAP:9104
TS23: distal segment of s-shaped body	Absent		GUDMAP:9104
TS23: medial segment of s-shaped body	Absent		GUDMAP:9104
TS23: proximal segment of s-shaped body	Absent		GUDMAP:9104
TS23: visceral epithelium of s-shaped body	Absent		GUDMAP:9104
TS23: parietal epithelium of s-shaped body	Absent		GUDMAP:9104
TS23: capillary loop renal corpuscle	Absent		GUDMAP:9104
TS23: visceral epithelium of capillary loop renal corpuscle	Absent		GUDMAP:9104
TS23: parietal epithelium of capillary loop renal corpuscle	Absent		GUDMAP:9104
TS23: presumptive mesangium of capillary loop renal corpuscle	Absent		GUDMAP:9104
TS23: presumptive endothelium of capillary loop renal corpuscle	Absent		GUDMAP:9104
TS23: associated interstitium of capillary loop renal corpuscle	Absent		GUDMAP:9104
TS23: maturing renal corpuscle	Absent		GUDMAP:9104
TS23: maturing glomerular tuft	Absent		GUDMAP:9104
TS23: glomerular capillary system of maturing glomerular tuft	Absent		GUDMAP:9104
TS23: glomerular basement membrane of maturing renal corpuscle	Absent		GUDMAP:9104
TS23: glomerular mesangium of maturing glomerular tuft	Absent		GUDMAP:9104
TS23: visceral epithelium of maturing renal corpuscle	Absent		GUDMAP:9104
TS23: Bowman's capsule of maturing renal corpuscle	Absent		GUDMAP:9104
TS23: parietal epithelium of maturing renal corpuscle	Absent		GUDMAP:9104
TS23: glomerular mesangium of maturing renal corpuscle	Absent		GUDMAP:9104
TS23: juxtaglomerular arteriole	Absent		GUDMAP:9104
TS23: cortical renal tubule	Absent		GUDMAP:9104
TS23: cortical early proximal tubule	Absent		GUDMAP:9104
TS23: anlage of loop of Henle of cortical renal tubule	Absent		GUDMAP:9104
TS23: cortical early distal tubule	Absent		GUDMAP:9104
TS23: renal connecting tubule	Absent		GUDMAP:9104
TS23: cortical collecting duct	Absent		GUDMAP:9104
TS23: renal cortical interstitium	Absent		GUDMAP:9104
TS23: renal cortical vasculature	Absent		GUDMAP:9104
TS23: renal medullary interstitium	Absent		GUDMAP:9104
TS23: renal medullary vasculature	Absent		GUDMAP:9104
TS23: medullary collecting duct	Absent		GUDMAP:9104
TS23: renal calyx	Absent		GUDMAP:9104
TS23: renal pelvis	Absent		GUDMAP:9104
TS23: pelvic urothelial lining	Absent		GUDMAP:9104
TS23: pelvic smooth muscle	Absent		GUDMAP:9104
TS23: perihilar interstitium	Absent		GUDMAP:9104
TS23: developing capillary loop stage nephron group	Absent		GUDMAP:9104
TS23: collecting duct	Absent		GUDMAP:9104
TS23: renal interstitium	Absent		GUDMAP:9104
TS23: renal vasculature	Absent		GUDMAP:9104
TS23: early nephron	Absent		GUDMAP:9104

GUDMAP:9105 ©

Specimen GUDMAP:9105: embryonic day 15.5 (more

)
Note: Labeling was visualized using BM purple. The low level expression control (Shh) showed only very weak expression. Thus, genes with a low level expression may not be detected. Some background signal was detected with the strong expression control (Wnt4).

Structure	Level	Image
TS23: ureter	Absent	GUDMAP:9105
TS23: urothelium of ureter	Absent	GUDMAP:9105
TS23: ureteral mesenchyme	Absent	GUDMAP:9105
TS23: ureteral mesenchyme subepithelial layer	Absent	GUDMAP:9105
TS23: ureteral smooth muscle layer	Absent	GUDMAP:9105
TS23: ureteral mesenchyme outer layer	Absent	GUDMAP:9105

GUDMAP:10911 ©

Specimen GUDMAP:10911: postnatal adult (more

)
Note: This animal was sexually mature. Labeling was visualized using BM purple.

Structure	Level	Pattern	Image	Note
TS28: urinary system	Present		GUDMAP:10911
TS28: metanephros	Present	Regionally restricted	GUDMAP:10911
TS28: renal cortex	Present	Regionally restricted	GUDMAP:10911
TS28: cortical renal tubule	Present	Regionally restricted	GUDMAP:10911
TS28: renal distal tubule	Present	Regionally restricted	GUDMAP:10911
TS28: distal straight tubule of renal cortex	Present		GUDMAP:10911
TS28: postmacula segment of distal straight tubule	Present		GUDMAP:10911
TS28: premacula segment of distal straight tubule of renal cortex	Present		GUDMAP:10911
TS28: distal convoluted tubule	Present	Regionally restricted	GUDMAP:10911	expression likely restricted to a subset of the distal convoluted tubule adjacent to the distal straight tubule
TS28: renal medulla	Present	Regionally restricted	GUDMAP:10911
TS28: outer renal medulla	Present	Regionally restricted	GUDMAP:10911
TS28: outer stripe of outer medulla	Present	Regionally restricted	GUDMAP:10911
TS28: loop of Henle of outer stripe of outer medulla	Present	Regionally restricted	GUDMAP:10911
TS28: distal straight tubule of outer stripe of outer medulla	Present		GUDMAP:10911
TS28: inner stripe of outer medulla	Present	Regionally restricted	GUDMAP:10911
TS28: loop of Henle of inner stripe of outer medulla	Present	Regionally restricted	GUDMAP:10911
TS28: premacula segment of distal straight tubule of inner stripe of inner medulla	Present		GUDMAP:10911
TS28: inner renal medulla	Present	Regionally restricted	GUDMAP:10911
TS28: loop of Henle, inner medullary portion	Present	Regionally restricted	GUDMAP:10911
TS28: thin ascending limb of inner medulla	Present	Regionally restricted	GUDMAP:10911	expression likely restricted to a small subset of thin ascending limb adjacent to the distal straight tubule
TS28: mature renal corpuscle	Absent		GUDMAP:10911
TS28: renal proximal tubule	Absent		GUDMAP:10911
TS28: renal connecting tubule	Absent		GUDMAP:10911
TS28: cortical collecting duct	Absent		GUDMAP:10911
TS28: renal cortical interstitium	Absent		GUDMAP:10911
TS28: renal cortical vasculature	Absent		GUDMAP:10911
TS28: proximal straight tubule of outer stripe of outer medulla	Absent		GUDMAP:10911
TS28: thin descending limb of inner stripe of outer medulla	Absent		GUDMAP:10911
TS28: outer medullary collecting duct	Absent		GUDMAP:10911
TS28: outer medullary interstitium	Absent		GUDMAP:10911
TS28: thin descending limb of inner medulla	Absent		GUDMAP:10911
TS28: inner medullary collecting duct	Absent		GUDMAP:10911
TS28: inner medullary interstitium	Absent		GUDMAP:10911
TS28: renal medullary vasculature	Absent		GUDMAP:10911

GUDMAP:10912 ©

Specimen GUDMAP:10912: postnatal adult (more

)
Note: This animal was sexually mature. This assay's probe was visualized using BM purple; it is blue. The section was also subjected to immunohistochemistry with an anti-Aqp1 antibody; that labeling is orange.

Structure	Level	Pattern	Image	Note
TS28: urinary system	Present		GUDMAP:10912
TS28: metanephros	Present	Regionally restricted	GUDMAP:10912
TS28: renal cortex	Present	Regionally restricted	GUDMAP:10912
TS28: cortical renal tubule	Present	Regionally restricted	GUDMAP:10912
TS28: renal distal tubule	Present	Regionally restricted	GUDMAP:10912
TS28: distal straight tubule of renal cortex	Present		GUDMAP:10912
TS28: postmacula segment of distal straight tubule	Present		GUDMAP:10912
TS28: premacula segment of distal straight tubule of renal cortex	Present		GUDMAP:10912
TS28: distal convoluted tubule	Present	Regionally restricted	GUDMAP:10912	expression likely restricted to a subset of the distal convoluted tubule adjacent to the distal straight tubule
TS28: renal medulla	Present	Regionally restricted	GUDMAP:10912
TS28: outer renal medulla	Present	Regionally restricted	GUDMAP:10912
TS28: outer stripe of outer medulla	Present	Regionally restricted	GUDMAP:10912
TS28: loop of Henle of outer stripe of outer medulla	Present	Regionally restricted	GUDMAP:10912
TS28: distal straight tubule of outer stripe of outer medulla	Present		GUDMAP:10912
TS28: inner stripe of outer medulla	Present	Regionally restricted	GUDMAP:10912
TS28: loop of Henle of inner stripe of outer medulla	Present	Regionally restricted	GUDMAP:10912
TS28: premacula segment of distal straight tubule of inner stripe of inner medulla	Present		GUDMAP:10912
TS28: inner renal medulla	Present	Regionally restricted	GUDMAP:10912
TS28: loop of Henle, inner medullary portion	Present	Regionally restricted	GUDMAP:10912
TS28: thin ascending limb of inner medulla	Present	Regionally restricted	GUDMAP:10912	expression likely restricted to a small subset of thin ascending limb adjacent to the distal straight tubule
TS28: mature renal corpuscle	Absent		GUDMAP:10912
TS28: renal proximal tubule	Absent		GUDMAP:10912
TS28: renal connecting tubule	Absent		GUDMAP:10912
TS28: cortical collecting duct	Absent		GUDMAP:10912
TS28: renal cortical interstitium	Absent		GUDMAP:10912
TS28: renal cortical vasculature	Absent		GUDMAP:10912
TS28: proximal straight tubule of outer stripe of outer medulla	Absent		GUDMAP:10912
TS28: thin descending limb of inner stripe of outer medulla	Absent		GUDMAP:10912
TS28: outer medullary collecting duct	Absent		GUDMAP:10912
TS28: outer medullary interstitium	Absent		GUDMAP:10912
TS28: thin descending limb of inner medulla	Absent		GUDMAP:10912
TS28: inner medullary collecting duct	Absent		GUDMAP:10912
TS28: inner medullary interstitium	Absent		GUDMAP:10912
TS28: renal medullary vasculature	Absent		GUDMAP:10912

GUDMAP:10913 ©

Specimen GUDMAP:10913: embryonic day 15.5 (more

)
Note: This assay's probe was visualized using BM purple; it is blue. The section was also subjected to immunohistochemistry with an anti-Aqp1 antibody; that labeling is orange.

Structure	Level	Pattern	Image	Note
TS23: urinary system	Present		GUDMAP:10913
TS23: metanephros	Present	Regionally restricted	GUDMAP:10913
TS23: renal medulla	Present	Regionally restricted	GUDMAP:10913
TS23: immature loop of Henle	Present	Regionally restricted	GUDMAP:10913	distal expression; expression likely restricted to the distal portion of the immature loop of Henle representative of early thin ascending loop of Henle as there is no overlap in expression with Aqp1 which is thin descending loop.
TS23: renal capsule	Absent		GUDMAP:10913
TS23: nephrogenic zone	Absent		GUDMAP:10913
TS23: renal vesicle	Absent		GUDMAP:10913
TS23: comma-shaped body	Absent		GUDMAP:10913
TS23: s-shaped body	Absent		GUDMAP:10913
TS23: capillary loop renal corpuscle	Absent		GUDMAP:10913
TS23: maturing renal corpuscle	Absent		GUDMAP:10913
TS23: anlage of loop of Henle of cortical renal tubule	Absent		GUDMAP:10913
TS23: renal connecting tubule	Absent		GUDMAP:10913
TS23: cortical early proximal tubule	Absent		GUDMAP:10913
TS23: cortical collecting duct	Absent		GUDMAP:10913
TS23: renal cortical interstitium	Absent		GUDMAP:10913
TS23: renal cortical vasculature	Absent		GUDMAP:10913
TS23: renal medullary interstitium	Absent		GUDMAP:10913
TS23: renal medullary vasculature	Absent		GUDMAP:10913
TS23: ureter	Absent		GUDMAP:10913
TS23: medullary collecting duct	Absent		GUDMAP:10913
TS23: renal pelvis	Absent		GUDMAP:10913
TS23: cortical early distal tubule	Ambiguous		GUDMAP:10913	possible very weak expression maturing nephron distal tubules, in a portion of the early distal tubule adjacent to the immature loop of Henle closest to the renal medulla.
TS23: cortical renal tubule of capillary loop nephron group	Absent		GUDMAP:10913
TS23: cortical renal tubule of maturing nephron group	Ambiguous		GUDMAP:10913
TS23: early distal tubule of maturing nephron	Ambiguous		GUDMAP:10913

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