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Gene Expression Data
Assay Details
Assay
Reference: J:84417 Laclef C, et al., Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. Mech Dev. 2003 Jun;120(6):669-79
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5516027
Gene symbol: Six1
Gene name: sine oculis-related homeobox 1
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 8.0; Six1tm1Mair/Six1+ (more )
Note: 4 somites
Structure Level Pattern Image Note
TS12: branchial arch Present 1A
TS12: head mesenchyme Present 1A
TS12: somite Present 1A
Specimen 1B: embryonic day 8.5; Six1tm1Mair/Six1+ (more )
Note: 11 somites
Structure Level Pattern Image Note
TS13: somite Strong Regionally restricted 1B Except the first three occipital somites.
TS13: otic placode Strong Regionally restricted 1B Expression is in mesenchymal cells and epithelial cells of the otic placode at the head level.
TS13: branchial arch Strong 1B
Specimen 1C: embryonic day 9.5; Six1tm1Mair/Six1+ (more )
Note: 27 somites
Structure Level Pattern Image Note
TS15: head mesenchyme Present 1C
TS15: otic pit Present 1C
TS15: somite Present 1C Newly formed somites are homogeneously stained.
TS15: olfactory placode Strong Regionally restricted 1C Expression is in epithelial cells.
Specimen 1D: embryonic day 9.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS15: branchial arch Strong 1D
TS15: dermomyotome Present 1D
TS15: dorsal root ganglion Present 1D
TS15: myotome Present 1D
TS15: otic pit Present 1D
TS15: embryo mesenchyme Present Regionally restricted 1D Expression is in the hypoglossal cord.
Specimen 1E: embryonic day 9.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS15: olfactory placode Strong 1E
TS15: nephrogenic cord Present 1E
Specimen 1F: embryonic day 9.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS15: paraxial mesenchyme Present Regionally restricted 1F There is lateral expression of unsegmented paraxial mesoderm.
Specimen 1G: embryonic day 10.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS17: branchial arch Strong 1G
TS17: nasal pit Strong 1G
TS17: dorsal root ganglion Present 1G
TS17: head mesenchyme Present 1G
TS17: otocyst Present 1G
TS17: somite Present 1G
TS17: limb Present Single cells 1G Expression is in cells invading the limb bud.
Specimen 1H: embryonic day 10.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Present 1H
TS17: somite Present 1H
TS17: cranial ganglion Present Regionally restricted 1H Expression is in proximal cranial ganglia.
Specimen 1I: embryonic day 10.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Present 1I
TS17: somite Present 1I
TS17: limb Present Single cells 1I Expression is in cells invading the limb bud.
Specimen 1J: embryonic day 10.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Present 1J
TS17: somite Present 1J
TS17: limb Present Single cells 1J Expression is in cells invading the limb bud.
Specimen 1K: embryonic day 12.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS20: somite Present Regionally restricted 1K Expression is in interlimb somites.
TS20: cranial ganglion Present 1K
TS20: dorsal root ganglion Present 1K
TS20: forelimb Present 1K Expression is in a posterior distally extended area and in an anterior area.
Specimen 2A: embryonic day 10.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS17: Rathke's pouch Strong 2A
TS17: otocyst Strong Regionally restricted 2A Expression is in the ventral part.
TS17: optic cup Absent 2A
Specimen 2B: embryonic day 10.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS17: otocyst epithelium Strong 2B
Specimen 2C,D: embryonic day 10.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Present 2C
TS17: somite Present 2C
TS17: mesonephric tubule Present 2D , 2C
Specimen 2E: embryonic day 11.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS19: eye Absent 2E
Specimen 2F: embryonic day 11.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS19: inner ear mesenchyme Strong Regionally restricted 2F Expression is in mesenchymal cells surrounding the otic vesicle.
TS19: endolymphatic appendage epithelium Strong 2F
Specimen 2G: embryonic day 11.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS19: somite Present Regionally restricted 2G Expression is in the dorso-medial lip and ventro-lateral lip of this immature somite.
TS19: dermomyotome Present 2G
TS19: myotome Present 2G
Specimen 2H: embryonic day 11.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS19: somite Present Regionally restricted 2H Expression is in the dorso-medial lip and ventro-lateral lip of this immature somite.
TS19: dermomyotome Present 2H
TS19: myotome Present 2H
Specimen 2I: embryonic day 12.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 2I
TS20: dermomyotome Present Regionally restricted 2I Expression is in the ventro-lateral extension of the dermomyotome.
TS20: skeletal muscle Present Regionally restricted 2I Expression is in dorsal and ventral muscle masses.
Specimen 2J: embryonic day 12.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 2J
TS20: dermomyotome Present Regionally restricted 2J Expression is in the ventro-lateral extension of the dermomyotome.
TS20: skeletal muscle Present Regionally restricted 2J Expression is in dorsal and ventral muscle masses.
Specimen 2K: postnatal adult; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS28: limb musculature Present 2K Thigh muscle.
Specimen 2L: postnatal adult; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS28: diaphragm Present 2L
Specimen 4A,C: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: otic capsule Present 4A , 4C
TS26: cochlear duct Present 4C , 4A These structures are unrecognizable in this mutant but staining is present.
TS26: semicircular duct Present 4C , 4A These structures are unrecognizable in this mutant but staining is present.
Specimen 4B,D: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: cochlear duct epithelium Present 4D , 4B
TS26: otic capsule Present 4D , 4B
Specimen 4E: embryonic day 11.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS19: inner ear Present 4E Otic vesicle expression/development in this mutant is the same as in wild-type.
Specimen 4F: embryonic day 11.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS19: inner ear Present 4F
Specimen 5A: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: olfactory epithelium Strong 5A Mutant show the absence of lateral reticulation of the nasal cavity.
TS26: head mesenchyme Present Regionally restricted 5A Expression is in dispersed mesenchyme surrounding the teeth primordium and the vibrissae follicules.
Specimen 5B: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: olfactory epithelium Strong 5B
TS26: head mesenchyme Present Regionally restricted 5B Expression is in dispersed mesenchyme surrounding the teeth primordium and the vibrissae follicules.
Specimen 5C: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: olfactory epithelium Strong 5C Mutant show the absence of lateral reticulation of the nasal cavity.
Specimen 5D: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: olfactory epithelium Strong 5D
Specimen 5E: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: olfactory epithelium Strong 5E Expression is in the nasal epithelium (epithelium is reduced in this mutant).
Specimen 5F: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: olfactory epithelium Strong 5F
Specimen 6A: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: eye Present Regionally restricted 6A Expression is in the lacrimal gland which is reduced and disorganized in this mutant.
TS26: parotid gland Absent 6A This structure is absent in the mutant.
Specimen 6B: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: eye Present Regionally restricted 6B Expression is in the lacrimal gland which is reduced and disorganized in this mutant.
TS26: parotid gland Absent 6B This structure is absent in the mutant.
Specimen 6C: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: parotid gland Present 6C
TS26: eye Present Regionally restricted 6C Expression is in the lacrimal gland.
Specimen 6D: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: parotid gland Present 6D
TS26: eye Present Regionally restricted 6D Expression is in the lacrimal gland.
Specimen 7A: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: pituitary gland Strong 7A Expression in this mutant is similar as seen in wild-type.
TS26: jaw Present 7A Expression in this mutant is similar as seen in wild-type.
TS26: nasal cavity epithelium Present 7A Expression in this mutant is similar as seen in wild-type.
TS26: tongue Present 7A Expression in this mutant is similar as seen in wild-type.
TS26: submandibular gland Present 7A Expression is similar, the gland is reduced in size.
TS26: thymus Absent 7A This structure is absent in the mutant.
Specimen 7B: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: pituitary gland Strong 7B
TS26: nasal cavity epithelium Present 7B
TS26: submandibular gland Present 7B
TS26: thymus Present 7B
TS26: tongue Present 7B
TS26: jaw Present Regionally restricted 7B Expression is in the mesenchyme surrounding the teeth primordia.
Specimen 7C: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: pituitary gland Strong 7C Expression in this mutant is the same as in wild-type.
Specimen 7D: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: pituitary gland Strong 7D
Specimen 7E: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: submandibular gland Present 7E Expression in this mutant is the same as in wild-type.
Specimen 7F: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: submandibular gland Present 7F
Specimen 7G: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: submandibular gland Present 7G Expression in this mutant is the same as in wild-type.
Specimen 7H: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: submandibular gland Present 7H
Specimen 7I: embryonic day 18.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS26: submandibular gland Present 7I The gland is reduced in size but expression in this mutant is the same as in wild-type.
Specimen 7J: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: submandibular gland Present 7J
Specimen 8A: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: thymus Present Single cells 8A
Specimen 8B: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: thymus Present Single cells 8B
Specimen 8C: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: thymus Present Single cells 8C
Specimen 9A: embryonic day 13.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS21: metanephros Absent 9A This structure is absent in this mutant.
Specimen 9B: embryonic day 13.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS21: metanephros Absent 9B
Specimen 9C: embryonic day 13.5; Six1tm1Mair/Six1tm1Mair (more )
Structure Level Pattern Image Note
TS21: embryo Present Regionally restricted 9C
Specimen 9D: embryonic day 13.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS21: embryo Present Regionally restricted 9D
Specimen 9E: embryonic day 18.5; Six1tm1Mair/Six1+ (more )
Structure Level Pattern Image Note
TS26: metanephros Absent 9E
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory