About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:77812 Perriton CL, et al., Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev Biol. 2002 Jul 1;247(1):26-46
Assay type: RNA in situ
MGI Accession ID: MGI:5505588
Gene symbol: Fgf8
Gene name: fibroblast growth factor 8
Probe: Fgf8 probe56
Visualized with: Alkaline phosphatase
Results
Specimen 3B E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: genital swelling Present Regionally restricted 3B E10.5 Expression domain restricted to anterior region of early urethral epithelium.
Specimen 3B E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: genital tubercle Present Regionally restricted 3B E11.5 Expression becomes progressively smaller and distally restricted, remaining localized to distal tip of urethral plate.
Specimen 3B E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: genital tubercle Present Regionally restricted 3B E12.5 Expression becomes progressively smaller and distally restricted.
Specimen 3B E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: genital tubercle Present Regionally restricted 3B E13.5 Expression becomes progressively smaller and distally restricted.
Specimen 3B E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: genital tubercle Absent 3B E14.5 Expression no longer detectable.
Specimen 4E: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: urethral plate Present Regionally restricted 4E Expression at distal tip of urethral plate. Size of domain decreases.
Specimen 4F: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: urethral plate Present Regionally restricted 4F Expression restricted to cells at ventral-most edge of distal urethral plate.
Specimen 4G: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: genital swelling of genital tubercle Present Regionally restricted 4G Expression in genital eminence localized to anterior part of urethral epithelium.
Specimen 4J: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: urethral plate Present Regionally restricted 4J Expression in small domain of distal urethral plate.
Specimen 4K: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: urethral plate Present Regionally restricted 4K Expression wthin ventral-most cells of distal urethral plate.
Specimen 6A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: genital tubercle Present Regionally restricted 6A Expression in urethral plate.
Specimen 6B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: cloaca Weak Regionally restricted 6B Expression in a small domain at anterior margin of cloacal epithelium, between paired genital swellings. Expression domain is reduced in size and intensity.
Specimen not shown: embryonic day 12.5; Shhtm1Chg/Shhtm1Chg (more )
Structure Level Pattern Image Note
TS20: genitourinary system Weak Expression downregulated.
Specimen 6C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: genitourinary system Present Regionally restricted 6C Expression restricted to small region distally.
Specimen 6D: embryonic day 13.5; Shhtm1Chg/Shhtm1Chg (more )
Structure Level Pattern Image Note
TS21: genitourinary system Absent 6D No expression in genital region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory