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Gene Expression Data
Assay Details
Assay
Reference: J:77801 Soo K, et al., Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo. Dev Biol. 2002 Jul 15;247(2):251-70
Assay type: RNA in situ
MGI Accession ID: MGI:5491501
Gene symbol: Fgf8
Gene name: fibroblast growth factor 8
Probe: Fgf8 probe52
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2H +/+: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future forebrain Present Regionally restricted 2H +/+ Expression was detected in the anterior neural ridge and ventral forebrain.
TS15: midbrain-hindbrain junction Present 2H +/+
Specimen 2H -/-: embryonic day 9.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS15: midbrain-hindbrain junction Present 2H -/- Expression was detected as in wild type.
Specimen 2I +/+: embryonic day 9.5 (more )
Note: Also stained for Hoxb1 (assay MGI:5491503), whose expression is indicated by a red arrow.
Structure Level Pattern Image Note
TS15: future forebrain Present Regionally restricted 2I +/+ Expression was detected in the anterior neural ridge and ventral forebrain.
TS15: midbrain-hindbrain junction Present 2I +/+
Specimen 2I -/-: embryonic day 9.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Note: Also stained for Hoxb1 (assay MGI:5491503), whose expression is indicated by a red arrow.
Structure Level Pattern Image Note
TS15: midbrain-hindbrain junction Present 2I -/- Expression was detected as in wild type.
Specimen 3D +/+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forebrain Present Regionally restricted 3D +/+ Expression was detected in the anterior commissure in the medial region of the ventral forebrain.
Specimen 3D -/-: embryonic day 10.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS17: forebrain Present Regionally restricted 3D -/- Expression was displaced to more lateral regions, leaving the medial region devoid of activity.
Specimen 5B +/+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Present 5B +/+
TS17: 1st branchial arch maxillary component Present 5B +/+
TS17: nasal epithelium Present 5B +/+
Specimen 5B -/-: embryonic day 10.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch maxillary component Present 5B -/- Expression was detected as in wild type.
TS17: nasal epithelium Present 5B -/- Expression was detected as in wild type.
TS17: 1st branchial arch mandibular component Present Regionally restricted 5B -/- Expression in the anterior margin of the proximal part of the mandibular process persisted, but was absent in the distal part.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory