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Gene Expression Data
Assay Details
Assay
Reference: J:77801 Soo K, et al., Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo. Dev Biol. 2002 Jul 15;247(2):251-70
Assay type: RNA in situ
MGI Accession ID: MGI:5491323
Gene symbol: Erbb4
Gene name: erb-b2 receptor tyrosine kinase 4
Probe: Erbb4 probe1
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2D +/+: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: diencephalon Present 2D +/+
TS15: future midbrain Present 2D +/+

Specimen 2D -/-: embryonic day 9.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS15: diencephalon Present 2D -/- Expression still extended to the anatomical restriction of the neural plate that may be equivalent to the border between the diencephalon and telencephalon.

Specimen 2K +/+: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: rhombomere 3 Present 2K +/+
TS15: rhombomere 5 Present 2K +/+

Specimen 2K -/-: embryonic day 9.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS15: rhombomere 3 Present 2K -/- Expression was maintained in the mutant.
TS15: rhombomere 5 Present 2K -/- Expression was maintained in the mutant.

Specimen not shown: embryonic day 9.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS15: rhombomere 3 Absent In one of four mutant embryos, expression was detected only in rhombomere 5 but was absent in rhombomere 3.
TS15: rhombomere 5 Present In one of four mutant embryos, expression was detected only in rhombomere 5 but was absent in rhombomere 3.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory