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Gene Expression Data
Assay Details
Assay
Reference: J:47724 McMahon JA, et al., Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 1998 May 15;12(10):1438-52
Assay type: RNA in situ
MGI Accession ID: MGI:5473670
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Probe: Islet1 probe5
Visualized with: Autoradiography
Results
Specimen 6A: embryonic day 10.5; Nogtm1Amc/Nog+ (more )
Note: Section at level of forelimb bud.
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6A Expression in differentiating motor neurons extending to hindlimb level.

Specimen 6B: embryonic day 10.5; Nogtm1Amc/Nogtm1Amc (more )
Note: Section at level of forelimb bud.
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6B Expression in differentiating motor neurons.

Specimen 6C: embryonic day 10.5; Nogtm1Amc/Nog+ (more )
Note: Section at level of forelimb bud.
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6C Expression in differentiating motor neurons extending to hindlimb level.

Specimen 6D: embryonic day 10.5; Nogtm1Amc/Nogtm1Amc (more )
Note: Section at level of forelimb bud.
Structure Level Pattern Image Note
TS17: neural tube lateral wall Weak Regionally restricted 6D Authors state that motor neuron formation was greatly reduced between limb buds.

Specimen 6E: embryonic day 10.5; Nogtm1Amc/Nog+ (more )
Note: Section at level of forelimb bud.
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 6E Expression in differentiating motor neurons extending to hindlimb level.

Specimen 6F: embryonic day 10.5; Nogtm1Amc/Nogtm1Amc (more )
Note: Section at level of forelimb bud.
Structure Level Pattern Image Note
TS17: neural tube lateral wall Absent 6F Authors state that motor neuron formation was completely absent at hindlimb levels.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory