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Gene Expression Data
Assay Details
Assay
Reference: J:35560 Zhou L, et al., Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J Histochem Cytochem. 1996 Oct;44(10):1183-93
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5463425
Gene symbol: Nkx2-1
Gene name: NK2 homeobox 1
Antibody: Anti-TTF-1
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 1A: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: trachea epithelium Strong 1A
TS18: thyroid gland Present 1A
TS18: esophagus Absent 1A
Specimen not shown: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: diencephalon Present Regionally restricted Expressed in the ventral region.
TS18: future pituitary Present Regionally restricted Expressed in the pars nervosa portion.
Specimen not shown: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: lobar bronchus Strong
TS20: main bronchus epithelium Strong
TS20: trachea epithelium Strong
Specimen 1B: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: trachea epithelium Strong 1B
TS21: thyroid gland Present 1B
TS21: esophagus Absent 1B
Specimen 1C: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: trachea epithelium Strong 1C
TS24: thyroid gland Present 1C
TS24: esophagus Absent 1C
Specimen 1D: postnatal adult (more )
Structure Level Pattern Image Note
TS28: trachea epithelium Present 1D
Specimen 2A: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: main bronchus epithelium Strong 2A
TS16: lung mesenchyme Absent 2A No expression in the splanchnic mesenchymal cells surrounding the main bronchi.
Specimen 2E: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: main bronchus epithelium Strong 2E
TS18: lung Strong Regionally restricted 2E Expressed in the epithelium of the lobar bronchus.
Specimen 3A: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: lung epithelium Present 3A More abundant in newly formed distal segmental bronchus. Expressed in bronchioles and distal acinar lung bud.
TS21: lobar bronchus epithelium Strong 3A
Specimen 3E: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: bronchiole epithelium Strong 3E
TS24: lung epithelium Strong 3E More abundantly expressed in the terminal lung buds.
Specimen 4A: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: bronchiole epithelium Strong 4A
TS25: lung alveolus Strong 4A Expressed in the differentiated Type II cells.
Specimen not shown: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: main bronchus epithelium Strong
Specimen 4E: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: bronchiole epithelium Present 4E
TS26: lung alveolus Present 4E Expressed in the differentiated Type II cells.
Specimen not shown: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: main bronchus epithelium Strong
Specimen 4I: postnatal adult (more )
Structure Level Pattern Image Note
TS28: bronchiole epithelium Strong 4I
TS28: alveolus epithelium Strong 4I Expressed in the differentiated Type II cells.
Specimen not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: main bronchus epithelium Strong
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory