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Gene Expression Data
Assay Details
Assay
Reference: J:112219 Patel SR, et al., Bmp4 and Noggin expression during early thymus and parathyroid organogenesis. Gene Expr Patterns. 2006 Dec;6(8):794-9
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5460800
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 9.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS15: 3rd branchial arch ectoderm Present 1A
TS15: embryo Present Regionally restricted 1A Expression is in mesenchyme caudal to the fourth arch and immediately adjacent to the surface ectoderm.
TS15: pharynx Present Regionally restricted 1A Expression is in the ventral pharynx just medial to the entrance of the third pouch.
TS15: 3rd branchial arch mesenchyme Present Single cells 1A Expression is in a few cells in the core.
TS15: 3rd branchial arch endoderm Absent 1A
Specimen 1C: embryonic day 10.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS17: 3rd branchial arch endoderm Present Regionally restricted 1C Expression is throughout the posterior aspect of the pouch in more ventral sections.
Specimen 1D: embryonic day 10.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS17: 3rd branchial groove Strong 1D
TS17: 3rd branchial arch endoderm Present Regionally restricted 1D In more dorsal sections expression is only those cells in close contact with the third pharyngeal cleft ectoderm.
TS17: 4th branchial arch Present Regionally restricted 1D Expression is posterior.
Specimen 1E: embryonic day 10.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS17: 3rd branchial arch endoderm Present Regionally restricted 1E Expression is ventral.
TS17: pharynx Present Regionally restricted 1E Expression is ventral.
TS17: 2nd branchial arch mesenchyme derived from neural crest Present Regionally restricted 1E Expression is in presumptive neural crest-derived mesenchyme cells immediately adjacent to expressing endodermal cells.
Specimen 1F: embryonic day 10.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS17: 3rd branchial arch endoderm Present Regionally restricted 1F Expression is posterior.
Specimen 1K: embryonic day 10.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS17: 3rd branchial arch Present Regionally restricted 1K Expression is in a small proportion of cells in the ventral pouch.
TS17: 3rd branchial arch mesenchyme derived from neural crest Present Regionally restricted 1K Expression is in presumptive neural crest-derived mesenchyme cells immediately adjacent to expressing endodermal cells.
Specimen 1Q: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS19: thymus/parathyroid primordium Present Regionally restricted 1Q Expression is ventral and posterior.
TS19: 3rd branchial arch mesenchyme Present Regionally restricted 1Q Expression is in the mesenchyme adjacent to the Bmp4-expressing region of the endoderm.
Specimen 1S: embryonic day 12.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS20: embryo mesenchyme Strong Regionally restricted 1S Expression is surrounding the thymus.
TS20: thymus primordium Strong Regionally restricted 1S
TS20: foregut gland Present Regionally restricted 1S Absent from the parathyroid, present in thymus.
Specimen 2A: embryonic day 9.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS15: 3rd branchial arch endoderm Absent 2A
Specimen 2C: embryonic day 10.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS17: 3rd branchial arch endoderm Present 2C
Specimen 2E: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS19: thymus/parathyroid primordium Present Regionally restricted 2E Expression is ventral and posterior.
TS19: 3rd branchial arch mesenchyme Present Regionally restricted 2E Expression is in the mesenchyme adjacent to the Bmp4-expressing region of the endoderm.
Specimen 2G: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS19: thymus/parathyroid primordium Present Regionally restricted 2G Expression is ventral and posterior.
TS19: 3rd branchial arch mesenchyme Present Regionally restricted 2G Expression is in the mesenchyme adjacent to the Bmp4-expressing region of the endoderm.
Specimen Not shown: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS19: 3rd branchial groove ectoderm Strong
TS19: 3rd branchial arch ectoderm Present Regionally restricted
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
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