Gene Expression Data
Assay Details
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Assay
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Reference:
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J:84418
Nakajima M, et al., Abnormal blood vessel development in mice lacking presenilin-1. Mech Dev. 2003 Jun;120(6):657-67
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:5443849
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Gene symbol:
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Pecam1
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Gene name:
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platelet/endothelial cell adhesion molecule 1
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Antibody:
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Anti-Pecam-1
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Detection system:
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Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
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Results
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Specimen
3A:
embryonic day 14.5
(more  )
Specimen
3A:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: blood vessel |
Present |
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3A
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Expression was detected in the skin of the dorsal median region of the trunk.
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Specimen
3B:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: blood vessel |
Present |
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3B
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Expression was detected in the skin of the dorsal median region of the trunk. Dilated blood vessels were noted.
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Specimen
3E:
embryonic day 14.5
(more )
Specimen
3E:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: blood vessel |
Present |
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3E
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Expression was detected in the vasculature of the stomach.
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Specimen
3F:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: blood vessel |
Present |
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3F
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Expression was detected in the vasculature of the stomach. Defective vascular remodeling in the stomach was noted.
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Specimen
4A & 4B:
embryonic day 13.5; Psen1tm1Hko/ Psen1tm1Hko
(more )
Note: Immunostaining was done without peroxidase treatment.
Specimen
4A & 4B:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Immunostaining was done without peroxidase treatment.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: blood vessel |
Present |
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4B
,
4A
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Expression was detected in the brain. Red blood cells accumulated in the ventricle. Vessels were dilated in the ganglionic eminence.
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Specimen
4C:
embryonic day 15.5; Psen1tm1Hko/ Psen1tm1Hko
(more )
Note: Immunostaining was done without peroxidase treatment.
Specimen
4C:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Immunostaining was done without peroxidase treatment.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: blood vessel |
Present |
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4C
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Expression was detected in the brain. Hemorrhages were noted in the ventricle, striatum, amygdala and thalamus. Vessel diameter increased.
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Specimen
4E:
embryonic day 15.5; Psen1tm1Hko/Psen1 +
(more )
Note: Immunostaining was done without peroxidase treatment.
Specimen
4E:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Psen1tm1Hko/Psen1+
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Immunostaining was done without peroxidase treatment.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: blood vessel |
Present |
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4E
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Expression was detected in the cortical region of the brain.
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Specimen
4F:
embryonic day 15.5; Psen1tm1Hko/ Psen1tm1Hko
(more )
Note: Immunostaining was done without peroxidase treatment.
Specimen
4F:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
|
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Note:
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Immunostaining was done without peroxidase treatment.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS23: blood vessel |
Present |
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4F
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Expression was detected in the cortical region of the brain. Vessel diameter was increased.
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Specimen
4G:
embryonic day 15.5; Psen1tm1Hko/Psen1 +
(more )
Note: Immunostaining was done without peroxidase treatment.
Specimen
4G:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Psen1tm1Hko/Psen1+
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Immunostaining was done without peroxidase treatment.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: blood vessel |
Present |
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4G
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Expression was detected in the amygdaloid region of the brain.
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Specimen
4H:
embryonic day 15.5; Psen1tm1Hko/ Psen1tm1Hko
(more )
Note: Immunostaining was done without peroxidase treatment.
Specimen
4H:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Immunostaining was done without peroxidase treatment.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: blood vessel |
Present |
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4H
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Expression was detected in the amygdaloid region of the brain. Vessel diameter was increased.
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