Gene Expression Data
Assay Details
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Assay
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Reference:
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J:84418
Nakajima M, et al., Abnormal blood vessel development in mice lacking presenilin-1. Mech Dev. 2003 Jun;120(6):657-67
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Assay type:
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In situ reporter (knock in)
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MGI Accession ID:
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MGI:5443837
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Gene symbol:
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Kdr
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Gene name:
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kinase insert domain protein receptor
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Reporter:
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lacZ
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Direct Detection
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Assay notes:
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Fixative: 0.2% glutaraldehyde, 1.5% formaldehyde.
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Results
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Specimen
2A:
embryonic day 11.5; Kdrtm1Jrt/Kdr +
(more  )
Specimen
2A:
(close  )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
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Age:
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embryonic day 11.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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| Structure |
Level |
Pattern |
Image |
Note |
| TS19: blood vessel |
Present |
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2A
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Expression was detected in the embryo.
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Specimen
2B:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 11.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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| Structure |
Level |
Pattern |
Image |
Note |
| TS19: blood vessel |
Present |
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2B
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Expression was detected in the embryo. Phenotypic abnormalities of intersomitic vessels were noted.
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Specimen
2C & 2E:
embryonic day 15.5; Kdrtm1Jrt/Kdr +
(more )
Specimen
2C & 2E:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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Specimen
2D & 2F:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: blood vessel |
Present |
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2F
,
2D
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Expression was detected in the brain. Phenotypic abnormalities of some vessels were noted. The density of capillaries was reduced and the width increased.
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Specimen
3C:
embryonic day 14.5; Kdrtm1Jrt/Kdr +
(more )
Specimen
3C:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: perineural vascular plexus |
Present |
Regionally restricted |
3C
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Expression was detected in the perineural plexus over the dorsal side of the spinal cord.
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Specimen
3D:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: perineural vascular plexus |
Present |
Regionally restricted |
3D
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LacZ-positive cells existed in the perineural plexus only in the most dorsal tip of the spinal cord.
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Specimen
5A:
embryonic day 14.5; Kdrtm1Jrt/Kdr +
(more )
Specimen
5A:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: blood vessel |
Present |
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5A
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Expression was detected in capillaries in the neocortical area.
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Specimen
5B:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: blood vessel |
Present |
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5B
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Expression was detected in capillaries in the neocortical area. Reduced numbers of capillary sprouting sites, increased diameter and aberrant branchings were noted.
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Specimen
5C:
embryonic day 14.5; Kdrtm1Jrt/Kdr +
(more )
Specimen
5C:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: blood vessel |
Present |
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5C
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Expression was detected in capillaries in the amygdaloid region.
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Specimen
5D:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Kdrtm1Jrt/Kdr+
Psen1tm1Hko/Psen1tm1Hko
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Other - See Notes
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: blood vessel |
Present |
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5D
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Expression was detected in capillaries in the amygdaloid region. Reduced numbers of capillary sprouting sites, increased diameter and aberrant branchings were noted.
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Analysis Tools
