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Gene Expression Data
Assay Details
Assay
Reference: J:49163 Kanzler B, et al., Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area. Development. 1998 Jul;125(14):2587-97
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5314804
Gene symbol: Hoxa2
Gene name: homeobox A2
Reporter: other (see notes)
Probe: neo probe
Probe preparation: labelled with radioactivity
Assay notes: Neomycin, included in the allele construct, was used as the reporter in this assay.
Results
Specimen 1D: embryonic day 12.0; Hoxa2tm1Grid/Hoxa2+ (more )
Structure Level Pattern Image Note
TS20: head mesenchyme Present Regionally restricted 1D Widely expressed throughout the second branchial arch mesenchyme.
TS20: middle ear mesenchyme Present Regionally restricted 1D No expression in the stapedial condensation.
Specimen 2B: embryonic day 13.5; Hoxa2tm1Grid/Hoxa2tm1Grid (more )
Structure Level Pattern Image Note
TS21: head mesenchyme Present Regionally restricted 2A/B Expressed in the region of the second branchial arch, including the condensation that generated the duplicated malleus.
TS21: Meckel's cartilage Absent 2A/B No expression in the normal structure derived from the first arch.
TS21: malleus pre-cartilage condensation Absent 2A/B No expression in the normal structure derived from the first arch.
TS21: otic capsule Absent 2A/B No expression in the normal structure derived from the first arch.
Specimen 2D: embryonic day 13.5; Hoxa2tm1Grid/Hoxa2tm1Grid (more )
Structure Level Pattern Image Note
TS21: head mesenchyme Present Regionally restricted 2C/D Expressed in the region of the second branchial arch, including the condensations that generated the duplicated Meckel's cartilage, external acoustic meatus and tympanic ring.
TS21: Meckel's cartilage Absent 2C/D No expression in the normal structure derived from the first arch.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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