About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:178455 Wang C, et al., Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development. Dev Biol. 2011 Dec 1;360(1):186-94
Assay type: Recombinase reporter
MGI Accession ID: MGI:5310721
Gene symbol: Six1
Gene name: sine oculis-related homeobox 1
Reporter: lacZ
Direct Detection
Results
Specimen Fig. 6B: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: genital tubercle Present Widespread 6B Staining is observed in the majority if not all of the genital tubercle mesenchyme in the distal region.

Specimen Fig. 6D: embryonic day 15.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: genital tubercle Present Widespread 6D Staining is observed in the majority if not all of the genital tubercle mesenchyme in the distal region.

Specimen Fig. 6F: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: genital tubercle Present Widespread 6F Staining is observed in the majority if not all of the genital tubercle mesenchyme in the proximal region. No staining is observed in the GT ectoderm.
TS21: perineal body Present Scattered 6F Staining is scattered within the urethral plate, perineum, bladder urothelium, and rectal epithelium.
TS21: primitive bladder Present Scattered 6F Staining is scattered within the urethral plate, perineum, bladder urothelium, and rectal epithelium.

Specimen Fig. 6H: embryonic day 15.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: genital tubercle Present Widespread 6H Staining is observed in the majority if not all of the genital tubercle mesenchyme in the proximal region. No staining is observed in the GT ectoderm.
TS23: perineal body Present Scattered 6H Staining is scattered within the urethral plate, perineum, bladder urothelium, and rectal epithelium.
TS23: rectum epithelium Present Scattered 6H Staining is scattered within the urethral plate, perineum, bladder urothelium, and rectal epithelium.
TS23: urothelium of bladder Present Scattered 6H Staining is scattered within the urethral plate, perineum, bladder urothelium, and rectal epithelium.
TS23: reproductive system Present Regionally restricted 6H No staining is observed in the preputial gland.

Specimen Fig. 6J: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: genital tubercle Present 6J Staining is observed in most of the mesenchyme of the dorsal genital tubercle and in the majority of the preputial fold mesenchyme, but not in the GT ectoderm.
TS21: mesenchyme of male preputial swelling Present 6J Staining is observed in most of the mesenchyme of the dorsal genital tubercle and in the majority of the preputial fold mesenchyme, but not in the GT ectoderm.
TS21: perineal body Present Scattered 6J Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.
TS21: primitive bladder Present Scattered 6J Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.
TS21: rectum epithelium Present Scattered 6J Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.

Specimen Fig. 6J: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: genital tubercle Present 6J Staining is observed in most of the mesenchyme of the dorsal genital tubercle and in the majority of the preputial fold mesenchyme, but not in the GT ectoderm.
TS21: mesenchyme of female preputial swelling Present 6J Staining is observed in most of the mesenchyme of the dorsal genital tubercle and in the majority of the preputial fold mesenchyme, but not in the GT ectoderm.
TS21: perineal body Present Scattered 6J Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.
TS21: primitive bladder Present Scattered 6J Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.
TS21: rectum epithelium Present Scattered 6J Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.

Specimen Fig. 6L: embryonic day 15.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: genital tubercle Present Widespread 6L Staining is observed in most of the mesenchyme of the dorsal genital tubercle and in the majority of the preputial fold mesenchyme, but not in the GT ectoderm.
TS23: mesenchyme of male preputial swelling Present Widespread 6L Staining is observed in most of the mesenchyme of the dorsal genital tubercle and in the majority of the preputial fold mesenchyme, but not in the GT ectoderm.
TS23: perineal body Present Scattered 6L Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.
TS23: rectum epithelium Present Scattered 6L Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.
TS23: urothelium of bladder Present Scattered 6L Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.

Specimen Fig. 6L: embryonic day 15.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: genital tubercle Present Widespread 6L Staining is observed in most of the mesenchyme of the dorsal genital tubercle and in the majority of the preputial fold mesenchyme, but not in the GT ectoderm.
TS23: mesenchyme of female preputial swelling Present Widespread 6L Staining is observed in most of the mesenchyme of the dorsal genital tubercle and in the majority of the preputial fold mesenchyme, but not in the GT ectoderm.
TS23: perineal body Present Scattered 6L Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.
TS23: rectum epithelium Present Scattered 6L Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.
TS23: urothelium of bladder Present Scattered 6L Staining is scattered in the perineum, bladder urothelium, and rectal epithelium.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/18/2025
MGI 6.24
The Jackson Laboratory