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Gene Expression Data
Assay Details
Assay
Reference: J:178455 Wang C, et al., Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development. Dev Biol. 2011 Dec 1;360(1):186-94
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5309173
Gene symbol: Six1
Gene name: sine oculis-related homeobox 1
Reporter: alkaline phosphatase
Direct Detection
Results
Specimen 5B: embryonic day 10.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS17: otocyst Strong 5B
TS17: nasal pit Strong 5B Expression is present in the nasal placode.
TS17: Rathke's pouch Strong 5B Expression is present in the pituitary placode.
TS17: dorsal root ganglion Present 5B
TS17: somite Present 5B
TS17: limb mesenchyme Present Regionally restricted 5B Staining is observed in muscle progenitor cells migrating into the limb bud.
Specimen 5C: embryonic day 10.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS17: somite Present 5C
TS17: metanephric mesenchyme Present 5C
TS17: anal region Strong Regionally restricted 5C Staining is observed in peri-cloacal mesenchyme (PCM) progenitor cells surrounding the cloaca.
Specimen 5D: embryonic day 10.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS17: anal region Strong Graded 5D Staining is observed surrounding the cloaca in peri-cloacal mesenchyme progenitor cells asymmetrically localized along the dorsoventral axis; there is a strong dorsal expression and weak ventral expression.
Specimen 5E: embryonic day 10.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS17: anal region Present Regionally restricted 5E Staining is observed in the peri-cloacal mesenchyme (PCM).
Specimen 5F: embryonic day 10.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS17: anal region Present Regionally restricted 5F Staining is observed in the dorsal peri-cloacal mesenchyme (dPCM).
Specimen 5G: embryonic day 10.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS17: anal region Present Regionally restricted 5G Staining is observed in the dorsal peri-cloacal mesenchyme (dPCM).
Specimen 5H: embryonic day 10.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS17: anal region Present Regionally restricted 5H Staining is observed in the peri-cloacal mesenchyme (PCM).
Specimen 5I: embryonic day 11.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS19: anal region Strong Regionally restricted 5I Staining is observed in the peri-cloacal mesenchyme (PCM).
Specimen 5J: embryonic day 11.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS19: anal region Present Regionally restricted 5J Staining is observed in the dorsal (d), intermediate (i) and ventral (v) peri-cloacal mesenchyme (PCM) but not in the intra-cloacal mesenchyme (ICM).
Specimen 5K: embryonic day 11.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS19: anal region Present Regionally restricted 5K Staining is observed in the dorsal (d), intermediate (i) and ventral (v) peri-cloacal mesenchyme (PCM) but not in the intra-cloacal mesenchyme (ICM).
Specimen 5L: embryonic day 11.5; Six1tm1(cre)Xli/Six1+ (more )
Structure Level Pattern Image Note
TS19: anal region Present Regionally restricted 5L Staining is observed in the peri-cloacal mesenchyme (PCM).
Specimen 6A: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: genital tubercle Present Regionally restricted 6A In the distal genital tubercle, staining is observed in the center of the genital tubercle dorsal to the developing urethra.
Specimen 6C: embryonic day 15.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: genital tubercle Present Regionally restricted 6C In the distal genital tubercle, staining is observed in the center of the genital tubercle dorsal to the developing urethra.
Specimen 6E: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: genital tubercle Present Widespread 6E In the proximal genital tubercle, staining is more broadly observed than in the distal region of the genital tubercle.
Specimen 6G: embryonic day 15.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: genital tubercle Present Regionally restricted 6G In the proximal genital tubercle, staining is more restricted at E15.5 compared to E13.5. Staining appears to be restricted to glans tissue.
Specimen 6I: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: genital tubercle Present Regionally restricted 6I Staining is observed in the perineum; it is absent from the dorsal half of the genital tubercle.
TS21: primitive bladder Present Regionally restricted 6I Staining is observed in the bladder neck region.
TS21: tail Present 6I Staining is observed at the tail.
TS21: rectum mesenchyme Present 6I Staining is observed in the mesenchyme surrounding the rectum.
Specimen 6K: embryonic day 15.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Six1tm1(cre)Xli/Six1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: genital tubercle Present Regionally restricted 6K Staining is observed in the genital tubercle, but it is not in the dorsal half of the tubercle nor in the preputial fold nor in the genital tubercle ectoderm.
TS23: bladder Present Regionally restricted 6K Staining is observed in the bladder neck region.
TS23: tail Present 6K Staining is observed at the tail.
TS23: rectum mesenchyme Present 6K Staining is observed in the mesenchyme surrounding the rectum.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory