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Gene Expression Data
Assay Details
Assay
Reference: J:80025 Wallis D, et al., The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development. 2003 Jan;130(1):221-32
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5302557
Gene symbol: Atoh1
Gene name: atonal bHLH transcription factor 1
Reporter: lacZ
Direct Detection
Results
Specimen 4G: postnatal day 0; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS27: saccule epithelium Present Regionally restricted 4G Expression is present in the hair cells.
Specimen 4H: postnatal day 0; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS27: saccule epithelium Present Regionally restricted 4H Expression is present in the hair cells; they are disorganized in the mutant.
Specimen 4I: postnatal day 0; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS27: crista ampullaris Present Regionally restricted 4I Expression is present in the hair cells.
Specimen 4J: postnatal day 0; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS27: crista ampullaris Present Regionally restricted 4J Expression is present in the hair cells. Their appearance is very similar to those seen in wild type.
Specimen 5A: embryonic day 15.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS23: cochlea epithelium Present Regionally restricted 5A Expression is present in the hair cells.
Specimen 5B: embryonic day 15.5; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS23: cochlea epithelium Present Regionally restricted 5B Expression is present in the hair cells; however, their rows are not as clearly defined as in wild type
Specimen 5C: embryonic day 17.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS25: organ of Corti Present Regionally restricted 5C Expression is present in the hair cells.
Specimen 5D: embryonic day 17.5; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS25: organ of Corti Present Regionally restricted 5D Expression is present in the hair cells; however, their rows are disorganized and their numbers are reduced in the basal cochlea.
Specimen 5E: postnatal day 0; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 5E Expression is present in the hair cells. This is a basal section.
Specimen 5F: postnatal day 0; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 5F Expression is present in the hair cells. However, there is degeneration in a basal to apical gradient. This is a basal section.
Specimen 5G: postnatal day 0; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 5G Expression is present in the hair cells. However, there is degeneration in a basal to apical gradient. This is a medial section.
Specimen 5H: postnatal day 0; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 5H Expression is present in the hair cells. However, there is degeneration in a basal to apical gradient. This is an apical section.
Specimen 5I: postnatal day 3; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 5I Expression is present in the hair cells. This is a basal section.
Specimen 5J: postnatal day 3; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 5J Expression is present in the hair cells. However, there is degeneration in a basal to apical gradient. This is a basal section.
Specimen 5K: postnatal day 3; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 5K Expression is present in the hair cells. However, there is degeneration in a basal to apical gradient. This is a medial section.
Specimen 5L: postnatal day 3; Atoh1tm2Hzo/Atoh1+, Gfi1tm1Sho/Gfi1tm1Sho (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 5L Expression is present in the hair cells. However, there is degeneration in a basal to apical gradient. This is an apical section.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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