Gene Expression Data
Assay Details
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Assay
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Reference:
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J:80025
Wallis D, et al., The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development. 2003 Jan;130(1):221-32
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:5302555
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Gene symbol:
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Tubb3
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Gene name:
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tubulin, beta 3 class III
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Results
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Specimen
3K:
embryonic day 17.5
(more  )
Specimen
3K:
(close  )
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Genetic Background:
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involves: 129S1/Sv * C57BL/6J
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
3L:
(close )
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Genetic Background:
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involves: 129S1/Sv * C57BL/6J
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Mutant Allele(s):
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Gfi1tm1Sho/Gfi1tm1Sho
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: vestibulocochlear nerve cochlear component |
Present |
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3L
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Expression is present in the neurons, but there is a different innervation pattern in the mutant compared to wild type.
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| TS25: organ of Corti |
Present |
Regionally restricted |
3L
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Expression is present in the cytoplasm of the outer hair cells, cells that do not normally express this protein, suggesting that hair cell differentiation is affected.
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Analysis Tools