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Gene Expression Data
Assay Details
Assay
Reference: J:166449 Nishino J, et al., Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci. 2010 Nov 10;30(45):15228-40
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5301084
Gene symbol: Fabp7
Gene name: fatty acid binding protein 7, brain
Antibody: anti B-FABP
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5C upper left: embryonic day 10.5 (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS17: enteric nervous system Absent 5C upper left No gliogenesis was detected.
Specimen 5C upper right: embryonic day 10.5; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS17: enteric nervous system Absent 5C upper right As in control, no gliogenesis was detected.
Specimen 5C lower left: embryonic day 18.5 (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS26: enteric nervous system Present Regionally restricted 5C lower left Expressed in glial cells.
Specimen 5C lower right: embryonic day 18.5; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS26: enteric nervous system Present Regionally restricted 5C lower right Fewer positive glial cells through the foregut, midgut and hindgut, relative to controls.
Specimen 5G upper left: embryonic day 10.5 (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS17: sympathetic nervous system Absent 5G upper left No gliogenesis was detected.
Specimen 5G upper right: embryonic day 10.5; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS17: sympathetic nervous system Absent 5G upper right As in control, no gliogenesis was detected.
Specimen 5G lower left: embryonic day 18.5 (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS26: sympathetic ganglion Present Regionally restricted 5G lower left Expressed in glial cells.
Specimen 5G lower right: embryonic day 18.5; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS26: sympathetic ganglion Present Regionally restricted 5G lower right Fewer positive glial cells relative to controls.
Specimen not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Absent No gliogenesis was detected.
Specimen not shown: embryonic day 10.5; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Absent As in control, no gliogenesis was detected.
Specimen not shown: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: dorsal root ganglion Present Regionally restricted Expressed in glial cells.
Specimen not shown: embryonic day 18.5; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Structure Level Pattern Image Note
TS26: dorsal root ganglion Present Regionally restricted Fewer positive glial cells relative to controls.
Specimen 6B middle left: postnatal day 0 (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present Regionally restricted 6B middle left inset , 6B middle left Expressed in glial cells.
Specimen 6B middle right: postnatal day 0; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Double labeled: green - Fabp7 (BFABP); red - Tubb3 (TuJ1; assay MGI:5301085).
Structure Level Pattern Image Note
TS27: myenteric nerve plexus Present Regionally restricted 6B middle right , 6B middle right inset Greatly reduced expression in glial cells, which were smaller and with fewer processes, compared with controls.
Specimen 7J wt BFABP: embryonic day 16.5 (more )
Note: Double labeled: green - Fabp7 (BFABP); red - phosphohistone.
Structure Level Pattern Image Note
TS24: enteric nervous system Present Regionally restricted 7J wt BFABP , 7J wt Merged Expressed in glial cells.
Specimen 7J mut BFABP: embryonic day 16.5; Lgi4tm1Sjm/Lgi4tm1Sjm (more )
Note: Double labeled: green - Fabp7 (BFABP); red - phosphohistone.
Structure Level Pattern Image Note
TS24: enteric nervous system Present Regionally restricted 7J mut Merged , 7J mut BFABP Fewer positive glial cells relative to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
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