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Gene Expression Data
Assay Details
Assay
Reference: J:176498 Al Alam D, et al., Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One. 2011;6(8):e23139
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5293746
Gene symbol: Axin2
Gene name: axin 2
Reporter: lacZ
Direct Detection
Results
Specimen 1E: embryonic day 11.5; Axin2tm1Wbm/Axin2tm1Wbm (more )
Structure Level Pattern Image Note
TS19: embryo Present Widespread 1E Authors report homogeneous expression throughout the embryo.
TS19: apical ectodermal ridge Strong 1E
TS19: mammary placode Present 1E
Specimen 1F: embryonic day 12.5; Axin2tm1Wbm/Axin2tm1Wbm (more )
Structure Level Pattern Image Note
TS20: limb epithelium Present Regionally restricted 1F Expression in the AER.
TS20: mammary bud Present 1F
TS20: vibrissa Present Regionally restricted 1F Expression in whisker placodes.
TS20: ear Strong 1F
TS20: somite Strong 1F
TS20: blood vessel Present Regionally restricted 1F Expression in developing vascular network underneath the skin.
Specimen 2I: embryonic day 11.5; Axin2tm1Wbm/Axin2tm1Wbm (more )
Structure Level Pattern Image Note
TS19: lung epithelium Present 2I
TS19: lung mesenchyme Weak 2I Lower levels of expression in lung mesenchyme
TS19: main bronchus epithelium Present 2I In trachea and primary bronchi, expression in both epithelium and adjacent mesenchyme.
TS19: main bronchus mesenchyme Present 2I In trachea and primary bronchi, expression in both epithelium and adjacent mesenchyme.
TS19: trachea epithelium Present 2I In trachea and primary bronchi, expression in both epithelium and adjacent mesenchyme.
TS19: trachea mesenchyme Present 2I In trachea and primary bronchi, expression in both epithelium and adjacent mesenchyme.
Specimen 2J: embryonic day 13.5; Axin2tm1Wbm/Axin2tm1Wbm (more )
Structure Level Pattern Image Note
TS21: lung epithelium Present 2J
TS21: lung mesenchyme Weak 2J Lower levels of expression in lung mesenchyme
TS21: main bronchus mesenchyme Present Regionally restricted 2J In primary bronchi, expression only in mesenchyme as a ring-like structure.
Specimen 2K: embryonic day 16.5; Axin2tm1Wbm/Axin2tm1Wbm (more )
Structure Level Pattern Image Note
TS24: lung epithelium Present 2K
TS24: lung mesenchyme Present 2K
Specimen 2L: embryonic day 18.5; Axin2tm1Wbm/Axin2tm1Wbm (more )
Structure Level Pattern Image Note
TS26: lung epithelium Present 2L
TS26: lung mesenchyme Present 2L
Specimen 3G: embryonic day 13.5; Axin2tm1Wbm/Axin2tm1Wbm (more )
Structure Level Pattern Image Note
TS21: lung Present 3G
Specimen 3H: embryonic day 13.5; Axin2tm1Wbm/Axin2tm1Wbm (more )
Structure Level Pattern Image Note
TS21: lung mesenchyme Present Regionally restricted 3H At the bronchial level, expression in mesenchyme adjacent to epithelium.
Specimen 3I: embryonic day 13.5; Axin2tm1Wbm/Axin2tm1Wbm (more )
Structure Level Pattern Image Note
TS21: lung epithelium Present Regionally restricted 3I In the distal lung, expression mainly in epithelium.
TS21: lung mesenchyme Weak Regionally restricted 3I Lower levels of expression in mesenchyme.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory