Nrg1 In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:43309 Meyer D, et al., Isoform-specific expression and function of neuregulin. Development. 1997 Sep;124(18):3575-86
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:5140130
Gene symbol:	Nrg1
Gene name:	neuregulin 1

Reporter:	lacZ
	Direct Detection
Assay notes:	This allele is specific for the type I isoform.

Results

2A ©

Specimen 2A: embryonic day 6.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

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Structure	Level	Pattern	Image	Note
TS9: embryo	Present		2A	There is broad expression in the embryo.

Specimen Not shown: embryonic day 6.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS9: embryo mesoderm	Present

2B ©

Specimen 2B: embryonic day 7.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS11: embryo	Present	Regionally restricted	2B	Expression is restricted to the rostral portion of the embryo.

Specimen Not shown: embryonic day 7.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS11: embryo mesoderm	Present

2C ©

Specimen 2C: embryonic day 8.0; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Image	Note
TS13: rhombomere 2	Present	2C	Expression is present in rhombomeres 2 and 4.
TS13: rhombomere 4	Present	2C	Expression is present in rhombomeres 2 and 4.
TS13: eye	Present	2C
TS13: head mesenchyme	Present	2C

Specimen Not shown: embryonic day 8.0; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS12: eye	Present	Regionally restricted		Expression is present in the eye stalk and optic placode.

2E ©

Specimen 2E: embryonic day 8.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS14: rhombomere 2	Present		2E
TS14: rhombomere 4	Present		2E
TS14: rhombomere 6	Present		2E
TS14: neural tube	Present	Regionally restricted	2E	Expression is present in the dorsal part of the spinal cord.
TS14: branchial arch	Present	Regionally restricted	2E	Expression is present in the cartilage.
TS14: eye	Present		2E
TS14: heart	Present		2E

Specimen Not shown: embryonic day 8.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS14: primitive ventricle endocardial tube	Present			Expression is present in the endocardium.

3A ©

Specimen 3A: embryonic day 9.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS15: glossopharyngeal preganglion	Present		3A
TS15: trigeminal preganglion	Present		3A
TS15: vagus preganglion	Present		3A
TS15: cranial preganglion	Present		3A	Expression is present in the geniculate ganglion.
TS15: heart	Present		3A
TS15: neural tube	Present	Regionally restricted	3A	Expression is present in the dorsal spinal cord.

3D ©

Specimen 3D: embryonic day 10.0; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS16: trigeminal ganglion	Present		3D
TS16: neural tube	Present	Regionally restricted	3D	Expression is present in the dorsal spinal cord.

3G ©

Specimen 3G: embryonic day 9.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS15: trigeminal preganglion	Present	Single cells	3G	Expression is present in cells with the shape characteristic of developing neurons.
TS15: rhombomere 2	Present		3G
TS15: branchial arch	Present	Regionally restricted	3G	Expression is present in the cartilage.
TS15: heart	Present		3G

3H ©

Specimen 3H: embryonic day 9.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS15: cranial preganglion	Present	Regionally restricted	3H	Expression is present in the geniculate ganglion.
TS15: rhombomere 4	Present		3H
TS15: heart	Present		3H

3I ©

Specimen 3I: embryonic day 9.5; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

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Structure	Level	Pattern	Image	Note
TS15: endocardial lining	Present		3I

4A ©

Specimen 4A: embryonic day 10.0; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS16: neural tube lateral wall	Present	Regionally restricted	4A	Expression is present in the dorsal column.

4B ©

Specimen 4B: embryonic day 12.0; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

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Structure	Level	Pattern	Image	Note
TS20: spinal cord lateral wall	Absent		4B

4C ©

Specimen 4C: embryonic day 18.0; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS26: dorsal root ganglion	Present	Scattered	4C

7A ©

Specimen 7A: embryonic day 18.0; Nrg1^tm2Cbm/Nrg1^tm2Cbm (more

)

Structure	Level	Pattern	Image	Note
TS26: superior colliculus	Present		7A
TS26: telencephalon ventricular layer	Present		7A

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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