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Gene Expression Data
Assay Details
Assay
Reference: J:135242 Kala K, et al., Analysis of the midbrain-hindbrain boundary cell fate using a boundary cell-specific Cre-mouse strain. Genesis. 2008 Jan;46(1):29-36
Assay type: Recombinase reporter
MGI Accession ID: MGI:4949433
Gene symbol: Tg(Hoxb7-cre)1Jpa
Gene name: transgene insertion 1, Juha Partanen
Reporter: lacZ
Direct Detection
Results
Specimen Fig. 1a: embryonic day 10.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant. Dorsal view.
Structure Level Pattern Image Note
TS17: midbrain-hindbrain junction Present 1a Staining is observed in a group of cells at the midbrain-hindbrain boundary.
Specimen Fig. 1b: embryonic day 10.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant. Side view.
Structure Level Pattern Image Note
TS17: midbrain-hindbrain junction Present 1b Staining is observed in a group of cells at the midbrain-hindbrain boundary.
Specimen Fig. 1f: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant. Dorsal view.
Structure Level Pattern Image Note
TS19: midbrain-hindbrain junction Present 1f Staining is observed in a group of cells at the midbrain-hindbrain boundary.
Specimen Fig. 1g: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant. Side view.
Structure Level Pattern Image Note
TS19: midbrain-hindbrain junction Present 1g Staining is observed in a group of cells at the midbrain-hindbrain boundary.
Specimen Fig. 2d: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: midbrain-hindbrain junction Present Regionally restricted 2d Staining is observed in cells at both sides of the posterior border of the Otx2 expression domain.
Specimen Fig. 4a: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: midbrain-hindbrain junction Present 4a Staining is observed in cells at the midbrain-hindbrain boundary.
TS19: midbrain Present Spotted 4a Staining is observed in a few cells in the inferior colliculus.
Specimen Fig. 4b: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: hindbrain Present Spotted 4d Staining is observed in a few cells in the isthmus.
TS19: midbrain-hindbrain junction Present Staining is observed in cells at the midbrain-hindbrain boundary.
Specimen Fig. 4c: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: midbrain-hindbrain junction Present 4c Staining is observed in cells at the midbrain-hindbrain boundary.
TS19: hindbrain Present Spotted 4c Staining is observed in a few cells in the isthmus.
Specimen Fig. 4d: embryonic day 14.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebellum Present Regionally restricted 4d Staining is observed in the anteromedial cerebellar plate.
Specimen Fig. 4e: embryonic day 14.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: midbrain tegmentum Present 4e Staining is observed bilaterally in the prospective midbrain tegmentum.
Specimen Fig. 4f: embryonic day 14.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: midbrain Present Scattered 4f Staining is observed in scattered cells in the isthmus region ventrally.
TS22: midbrain-hindbrain junction Present 4f Staining is observed at the midbrain-hindbrain junction dorsally.
Specimen Fig. 4g: embryonic day 18.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: cerebellum Present 4g Staining is observed in mainly in the cell population in the area between the midbrain tegmentum, cerebellum and pons.
TS26: midbrain tegmentum Present 4g Staining is observed in mainly in the cell population in the area between the midbrain tegmentum, cerebellum and pons.
TS26: pons Present 4g Staining is observed in mainly in the cell population in the area between the midbrain tegmentum, cerebellum and pons.
Specimen Fig. 4h: embryonic day 18.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: midbrain Present 4h Staining is observed bilaterally in the ventral midbrain, ventral tegmental area, and tegmentum.
TS26: midbrain tegmentum Present 4h Staining is observed bilaterally in the ventral midbrain, ventral tegmental area, and tegmentum.
Specimen Fig. 4i: embryonic day 18.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: cerebellum Present Spotted 4i Staining is observed in some cells near the midline of the cerebellum.
TS26: inferior colliculus Present 4i Staining is observed in the inferior colliculus.
Specimen Fig. 4j: postnatal day 60; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: periaqueductal grey Present 4j Staining is observed in the ventrolateral periaqueductal gray.
Specimen Fig. 4k: postnatal day 60; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: midbrain tegmentum Present Regionally restricted 4k Staining is observed in the ventral tegmental area.
Specimen Fig. 4l: postnatal day 60; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant. Parasagittal section.
Structure Level Pattern Image Note
TS28: inferior colliculus Present 4l
TS28: cerebellum Present Spotted 4l Staining is observed in some cells in the cerebellum.
TS28: midbrain Present Regionally restricted 4l Staining is observed in the isthmus.
TS28: midbrain tegmentum Present Regionally restricted 4l Staining is observed in the ventral tegmental area.
Specimen Fig. 5a: postnatal day 60; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: midbrain tegmentum Present 5a , 5c Staining is observed in cells in the VTA and in cells intermingling with tyrosine hydroxylase-expressing fibers extending dorsocaudally from ventral tegmental area (VTA).
Specimen Fig. 5b: postnatal day 60; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant. Coronal section.
Structure Level Pattern Image Note
TS28: cerebellum Present 5b
Specimen Fig. 5d: postnatal day 60; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: brain Present 5d Staining is observed in cells containing Nissl substance, indicating neuronal identity.
Specimen Fig. 5h: postnatal day 60; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant. Coronal section.
Structure Level Pattern Image Note
TS28: midbrain Present 5h Staining is observed in cells near but distinct from nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd)-expressing cholinergic nuclei in the mesopontine tegmentum and laterodorsal tegmental nucleus.
Specimen Fig. 5i: postnatal day 60; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Hoxb7-cre)1Jpa/0 (more )
Note: Conditional mutant. Coronal section.
Structure Level Pattern Image Note
TS28: midbrain Present 5i Staining is observed in cells near but distinct from nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd)-expressing cholinergic nuclei in the pedunculopontine tegmental nucleus.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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