About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:150086 Kiso M, et al., The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9292-7
Assay type: Immunohistochemistry
MGI Accession ID: MGI:4844118
Gene symbol: Sox21
Gene name: SRY (sex determining region Y)-box 21
Antibody: Anti-Sox21
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2D: postnatal day 5 (more )
Note: Double labeled: green - Sox21; red - Krt14 (assay MGI:4844111).
Structure Level Pattern Image Note
TS28: hair follicle Strong Regionally restricted 2D Expression was detected along the hair shaft.
TS28: hair outer root sheath Absent 2D
Specimen 2E: postnatal day 5 (more )
Note: Double labeled: green - Sox21; red - Krt71 (assay MGI:4844112).
Structure Level Pattern Image Note
TS28: hair follicle Strong Regionally restricted 2E Expression was detected along the hair shaft.
TS28: hair inner root sheath Absent 2E
Specimen 2F & F'': postnatal day 5 (more )
Note: Double labeled: green - Sox21; red - Krt32 (assay MGI:4844113).
Structure Level Pattern Image Note
TS28: hair cuticle Present 2F'' , 2F
Specimen 2G & G'': postnatal day 5 (more )
Note: Double labeled: green - Sox21; red - Krt31 (assay MGI:4844116).
Structure Level Pattern Image Note
TS28: hair cuticle Present 2G , 2G''
Specimen 2H & H'': postnatal day 5 (more )
Note: Double labeled: green - Sox21; red - Pcna (assay MGI:4844114).
Structure Level Pattern Image Note
TS28: dermis papillary layer Present Regionally restricted 2H , 2H'' Expression was detected in the proximal postmitotic cells.
Specimen S3A Filaggrin/Sox21: postnatal day 5 (more )
Note: Double labeled: green - Sox21; red - Flg (assay MGI:4844139).
Structure Level Pattern Image Note
TS28: epidermis Weak Regionally restricted S3A Filaggrin/Sox21 Weak expression was detected in the infundibulum and interfollicular epidermis.
Specimen S3A K10/Sox21: postnatal day 5 (more )
Note: Double labeled: green - Sox21; red - Krt10 (assay MGI:4844140).
Structure Level Pattern Image Note
TS28: epidermis Weak Regionally restricted S3A K10/Sox21 Weak expression was detected in the infundibulum and interfollicular epidermis.
Specimen S3A K14/Sox21: postnatal day 5 (more )
Note: Double labeled: green - Sox21; red - Krt14 (assay MGI:4844111).
Structure Level Pattern Image Note
TS28: epidermis Weak Regionally restricted S3A K14/Sox21 Weak expression was detected in the infundibulum and interfollicular epidermis.
Specimen S3A PCNA/Sox21: postnatal day 5 (more )
Note: Double labeled: green - Sox21; red - Pcna (assay MGI:4844114).
Structure Level Pattern Image Note
TS28: epidermis Weak Regionally restricted S3A PCNA/Sox21 Weak expression was detected in the infundibulum and interfollicular epidermis.
Specimen S3C P7: postnatal day 7 (more )
Note: Anagen phase.
Structure Level Pattern Image Note
TS28: hair follicle Strong S3C Sox21+/+ P7 Strong expression was detected in the anagen-stage hair follicle.
TS28: epidermis Present S3C Sox21+/+ P7 inset , S3C Sox21+/+ P7
Specimen S3C P15: postnatal day 15 (more )
Note: Catagen.
Structure Level Pattern Image Note
TS28: hair follicle Present S3C Sox21+/+ P15
TS28: epidermis Present S3C Sox21+/+ P15 , S3C Sox21+/+ P15 inset
Specimen S3C P19: postnatal day 19 (more )
Note: Telogen phase.
Structure Level Pattern Image Note
TS28: hair follicle Absent S3C Sox21+/+ P19 Expression became undetectable in telogen stage as hair follicles regressed.
TS28: epidermis Present S3C Sox21+/+ P19 , S3C Sox21+/+ P19 inset
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory