Defa4 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:150374 Garcia MI, et al., LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine. Dev Biol. 2009 Jul 1;331(1):58-67
Assay type:	RNA in situ
MGI Accession ID:	MGI:4352752
Gene symbol:	Defa4
Gene name:	defensin, alpha, 4

Probe:	Cryptdin 4 probe1
Probe preparation:	Antisense labelled with digoxigenin RNA

Results

4A WT ©

Specimen 4A WT: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: ileum	Trace	Regionally restricted	4A WT	Wild type sections displayed little if any positivity.

4A KO ©

Specimen 4A KO: embryonic day 18.5; Lgr5^tm1Ah/Lgr5^tm1Ah (more

)

Structure	Level	Pattern	Image	Note
TS26: ileum	Present	Regionally restricted	4A KO	Expression was detected in the intervillus region of the epithelium.

4F WT ©

Specimen 4F WT: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: duodenum	Trace		4F WT

4F KO ©

Specimen 4F KO: embryonic day 18.5; Lgr5^tm1Ah/Lgr5^tm1Ah (more

)

Structure	Level	Pattern	Image	Note
TS26: duodenum	Present	Regionally restricted	4F KO	The Paneth cell differentiation program was precociously induced in the duodenum of knock-out mice.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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