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Gene Expression Data
Assay Details
Assay
Reference: J:119269 Caqueret A, et al., Laminar organization of the early developing anterior hypothalamus. Dev Biol. 2006 Oct 1;298(1):95-106
Assay type: RNA in situ
MGI Accession ID: MGI:3703599
Gene symbol: Sim1
Gene name: single-minded family bHLH transcription factor 1
Results
Specimen 1B: embryonic day 12.5; Sim1tm1Fan/Sim1+ (more )
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 1B Expression was detected in the anterior hypothalamus but was absent from the most ventral aspect.

Specimen 2A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 2A Expression was detected in the anterior hypothalamus.
TS20: hypothalamus mantle layer Present Regionally restricted 2A Expression was detected in the mantle layer of the anterior hypothalamus in medial and lateral domains that extend from the ventricular layer to the surface of the brain.

Specimen 2E: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 2E Expression was detected in the anterior hypothalamus.
TS20: hypothalamus mantle layer Present Regionally restricted 2E Expression was detected in the mantle layer of the anterior hypothalamus in medial and lateral domains that extend from the ventricular layer to the surface of the brain.

Specimen 2I: embryonic day 12.5; Sim1tm1Fan/Sim1tm1Fan (more )
Structure Level Pattern Image Note
TS20: hypothalamus Weak Regionally restricted 2I Expression was detected in the anterior hypothalamus but the level was decreased in the mutant compared to wild type.

Specimen 2M: embryonic day 12.5; Sim1tm1Fan/Sim1tm1Fan (more )
Structure Level Pattern Image Note
TS20: hypothalamus Weak Regionally restricted 2M Expression was detected in the anterior hypothalamus but the level was decreased in the mutant compared to wild type.

Specimen 2Q: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 2Q Expression was detected in the anterior hypothalamus.
TS20: hypothalamus mantle layer Present Regionally restricted 2Q Expression was detected in the mantle layer of the anterior hypothalamus in medial and lateral domains that extend from the ventricular layer to the surface of the brain.

Specimen 2S: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 2S Expression was detected in the anterior hypothalamus.
TS20: hypothalamus mantle layer Present Regionally restricted 2S Expression was detected in the mantle layer of the anterior hypothalamus in medial and lateral domains that extend from the ventricular layer to the surface of the brain.

Specimen 2U: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 2U Expression was detected in the anterior hypothalamus.
TS20: hypothalamus mantle layer Present Regionally restricted 2U Expression was detected in the mantle layer of the anterior hypothalamus in medial and lateral domains that extend from the ventricular layer to the surface of the brain.

Specimen 2X: embryonic day 12.5; Sim1tm1Fan/Sim1tm1Fan (more )
Structure Level Pattern Image Note
TS20: hypothalamus Weak Regionally restricted 2X Expression was detected in the anterior hypothalamus but the level was decreased in the mutant compared to wild type.

Specimen 2Z: embryonic day 12.5; Sim1tm1Fan/Sim1tm1Fan (more )
Structure Level Pattern Image Note
TS20: hypothalamus Weak Regionally restricted 2Z Expression was detected in the anterior hypothalamus but the level was decreased in the mutant compared to wild type.

Specimen 2AB: embryonic day 12.5; Sim1tm1Fan/Sim1tm1Fan (more )
Structure Level Pattern Image Note
TS20: hypothalamus Weak Regionally restricted 2AB Expression was detected in the anterior hypothalamus but the level was decreased in the mutant compared to wild type.

Specimen 3F: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: diencephalon Present Regionally restricted 3F Expression in the mantle layer of the anterior hypothalamus extends to the lateral border of the neural tube with a distinct medial boundary.

Specimen 4M: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted 4M Expression was detected in the mantle layer of the anterior hypothalamus in a lateral domain extending to the surface of the neural tube.

Specimen 4Q: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted 4Q Expression was detected in the mantle layer of the anterior hypothalamus in a lateral domain extending to the surface of the neural tube.

Specimen 5M: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hypothalamus mantle layer Present Regionally restricted 5M Expression was detected in the mantle layer of the anterior hypothalamus in medial and lateral domains that extend from the ventricular layer to the surface of the brain.

Specimen 5Q: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hypothalamus mantle layer Present Regionally restricted 5Q Expression was detected in the mantle layer of the anterior hypothalamus in medial and lateral domains that extend from the ventricular layer to the surface of the brain.

Specimen 6A: embryonic day 12.5 (more )
Note: Specimen was treated with BrdU.
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 6A Expression was detected in anterior hypothalamus.

Specimen 6C: embryonic day 12.5 (more )
Note: Specimen was treated with BrdU.
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 6C Expression was detected in anterior hypothalamus.

Specimen 6E: embryonic day 12.5; Sim1tm1Fan/Sim1tm1Fan (more )
Note: Specimen was treated with BrdU.
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 6E Expression was detected in a more narrow domain of the anterior hypothalamus compared to wild type.

Specimen 6G: embryonic day 12.5; Sim1tm1Fan/Sim1tm1Fan (more )
Note: Specimen was treated with BrdU.
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 6G Expression was detected in a more narrow domain of the anterior hypothalamus compared to wild type.

Specimen 6K: embryonic day 12.5 (more )
Note: Specimen was treated with BrdU.
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 6K Expression was detected in anterior hypothalamus.

Specimen 7B: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: hypothalamus Present Regionally restricted 7B Expression was detected in a domain immediately adjacent to the third ventricle, which corresponds to the paraventricular nucleus.

Specimen 7F: embryonic day 15.5; Sim1tm1Jlmd/Sim1tm1Jlmd (more )
Structure Level Pattern Image Note
TS23: hypothalamus Weak Regionally restricted 7F Expression was reduced in the paraventricular and supraoptic nuclei of the mutant compared to wild type. Transcript was detected in a domain located midway between the third ventricle and the surface of the brain.

Specimen 7L: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: hypothalamus Present Regionally restricted 7L Expression was detected in a domain immediately adjacent to the third ventricle, which corresponds to the paraventricular nucleus.

Specimen 7P: embryonic day 15.5; Sim1tm1Jlmd/Sim1tm1Jlmd (more )
Structure Level Pattern Image Note
TS23: hypothalamus Weak Regionally restricted 7P Expression was reduced in the paraventricular and supraoptic nuclei of the mutant compared to wild type. Transcript was detected in a domain located midway between the third ventricle and the surface of the brain.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory