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Gene Expression Data
Assay Details
Assay
Reference: J:104488 Ozaki H, et al., Six1 controls patterning of the mouse otic vesicle. Development. 2004 Feb;131(3):551-62
Assay type: RNA in situ
MGI Accession ID: MGI:3653244
Gene symbol: Six1
Gene name: sine oculis-related homeobox 1
Probe: Six1 cDNA3
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1C +/+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: branchial arch Present 1C +/+
TS17: embryo Present 1C +/+
Specimen 1C -/-: embryonic day 10.5; Six1tm1Kwk/Six1tm1Kwk (more )
Structure Level Pattern Image Note
TS17: embryo Absent 1C -/-
Specimen 4A: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: otic placode Weak 4A
TS13: surface ectoderm Weak Regionally restricted 4A Expression was weak in the surface ectoderm surrounding the otic placode.
Specimen 4B: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otic pit Present 4B
Specimen 4C: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 4C Expression was detected in the otic vesicle except in the dorsalmost region.
TS15: inner ear mesenchyme Present Regionally restricted 4C Expression was detected in the periotic mesenchyme.
Specimen 4D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 4D Expression was detected in the ventral half of the otic vesicle.
Specimen 4E: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: saccule Present Regionally restricted 4E Expression was detected in the cochlea.
Specimen 4F: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cochlea Present 4F
Specimen not shown: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: cochlear duct Present
Specimen 7G: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Strong Regionally restricted 7G Expression was abundant in the ventral region.
Specimen 7H: embryonic day 10.5; Shhtm1Chg/Shhtm1Chg (more )
Structure Level Pattern Image Note
TS17: otocyst Strong Regionally restricted 7H Expression was abundant in the ventral region as in wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory