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Gene Expression Data
Assay Details
Assay
Reference: J:103780 Maurer ME, et al., Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. J Cell Sci. 2005 Nov 15;118(Pt 22):5345-55
Assay type: Immunohistochemistry
MGI Accession ID: MGI:3617839
Gene symbol: Dab2
Gene name: disabled 2, mitogen-responsive phosphoprotein
Antibody: anti-Dab2
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2B +/?: embryonic day 6.5; Dab2tm1.1Cpr/Dab2+ (more )
Note: Littermate control; embryos were either +/+ or +/-. Double labeled: green - Dab2; red - Eea1 (assay MGI:3617842)
Structure Level Pattern Image Note
TS9: extraembryonic visceral endoderm Present 2B Expression is at the apical surface and internal vesicles.
Specimen 2D -/-: embryonic day 6.5; Dab2tm1.1Cpr/Dab2tm1.1Cpr (more )
Note: Double labeled: green - Dab2; red - Eea1 (assay MGI:3617842)
Structure Level Pattern Image Note
TS9: extraembryonic visceral endoderm Absent 2D
Specimen 3A,C: embryonic day 6.5; Dab2tm1.1Cpr/Dab2+ (more )
Note: Littermate control; embryos were either +/+ or +/-. Double labeled: green - Dab2; red - Ldlrap1 (assay MGI:3617855).
Structure Level Pattern Image Note
TS9: extraembryonic visceral endoderm Present 3A , 3C
Specimen 4D: embryonic day 6.5; Dab2tm1.1Cpr/Dab2+ (more )
Note: Littermate control; embryos were either +/+ or +/-.
Structure Level Pattern Image Note
TS9: extraembryonic visceral endoderm Present 4D Expression is both diffuse as well as vesicle-associated, at both the apical and to as lesser extent the basolateral surface.
Specimen 5C: postnatal adult (more )
Structure Level Pattern Image Note
TS28: renal proximal tubule Present Regionally restricted 5C Expression is localized to the apical brush-border of the proximal tubule epithelium.
Specimen 5D: postnatal adult; Dab2tm1.1Cpr/Dab2tm1.1Cpr (more )
Structure Level Pattern Image Note
TS28: metanephros Absent 5D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory