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Gene Expression Data
Assay Details
Assay
Reference: J:65298 Corbin JG, et al., The gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development. 2000 Dec;127(23):5007-20
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:3616973
Gene symbol: Dlx2
Gene name: distal-less homeobox 2
Reporter: lacZ
Direct Detection
Results
Specimen 2C: embryonic day 12.5; Dlx2tm1Fsh/Dlx2+ (more )
Structure Level Pattern Image Note
TS20: caudal ganglionic eminence Present Regionally restricted 2C Expression is present in the ventricular zone and subventricular zone.
TS20: lateral ganglionic eminence Present Regionally restricted 2C Expression is present in the ventricular zone and subventricular zone.
TS20: medial ganglionic eminence Present Regionally restricted 2C Expression is present in the ventricular zone and subventricular zone.
TS20: telencephalon ventricular layer Present 2C
TS20: diencephalon Present Regionally restricted 2C Expression is present in the ventral diencephalon.
Specimen 2D: embryonic day 12.5; Dlx2tm1Fsh/Dlx2+, Gsx2tm1Ssp/Gsx2tm1Ssp (more )
Structure Level Pattern Image Note
TS20: lateral ganglionic eminence Present Regionally restricted 2D There is an absence of expression in all but the most ventral aspect of the lateral ganglionic eminence.
TS20: medial ganglionic eminence Present Regionally restricted 2D Expression is also reduced in the ventricular zone.
Specimen 3C: embryonic day 15.5; Dlx2tm1Fsh/Dlx2+, Gsx2tm1Ssp/Gsx2+ (more )
Structure Level Pattern Image Note
TS23: corpus striatum Present Regionally restricted 3C Expression is present the subventricular zone.
TS23: lateral ganglionic eminence Present Regionally restricted 3C Expression is present in the ventricular zone.
Specimen 3D: embryonic day 15.5; Dlx2tm1Fsh/Dlx2+, Gsx2tm1Ssp/Gsx2tm1Ssp (more )
Structure Level Pattern Image Note
TS23: corpus striatum Present Regionally restricted 3D Expression is present the subventricular zone.
TS23: lateral ganglionic eminence Absent 3D There is no expression in the ventricular zone.
Specimen 7A: embryonic day 15.5; Dlx2tm1Fsh/Dlx2+, Gsx2tm1Ssp/Gsx2+ (more )
Structure Level Pattern Image Note
TS23: olfactory lobe Present 7A
Specimen 7B: embryonic day 15.5; Dlx2tm1Fsh/Dlx2+, Gsx2tm1Ssp/Gsx2tm1Ssp (more )
Structure Level Pattern Image Note
TS23: olfactory lobe Present 7B Relative to wild type, there is a significant reduction in the level of expression in the subventricular zone of the mutant.
Specimen 7E: embryonic day 18.5; Dlx2tm1Fsh/Dlx2+ (more )
Structure Level Pattern Image Note
TS26: main olfactory bulb Present 7E
Specimen 7F: embryonic day 18.5; Dlx2tm1Fsh/Dlx2+, Gsx2tm1Ssp/Gsx2tm1Ssp (more )
Structure Level Pattern Image Note
TS26: main olfactory bulb Present 7F Compared to wild type, expression is at near normal levels in the mutant.
Specimen 7M: embryonic day 15.5; Dlx2tm1Fsh/Dlx2+ (more )
Structure Level Pattern Image Note
TS23: cerebral cortex marginal layer Present 7M
TS23: cerebral cortex subventricular zone Present 7M
Specimen 7N: embryonic day 15.5; Dlx2tm1Fsh/Dlx2+, Gsx2tm1Ssp/Gsx2tm1Ssp (more )
Structure Level Pattern Image Note
TS23: cerebral cortex marginal layer Present 7N Expression levels are comparable to those seen in wild type.
TS23: cerebral cortex subventricular zone Present 7N Expression levels are comparable to those seen in wild type.
Specimen not shown: embryonic day 18.5; Dlx2tm1Fsh/Dlx2+ (more )
Structure Level Pattern Image Note
TS26: telencephalon ventricular layer Present Regionally restricted Expression is present in the ventricular zone.
Specimen not shown: embryonic day 18.5; Dlx2tm1Fsh/Dlx2+, Gsx2tm1Ssp/Gsx2tm1Ssp (more )
Structure Level Pattern Image Note
TS26: main olfactory bulb Present Regionally restricted Expression is present in immature interneurons.
TS26: telencephalon ventricular layer Present Regionally restricted Expression is present in the ventricular zone.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory