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Gene Expression Data
Assay Details
Assay
Reference: J:83132 Settle SH Jr, et al., Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol. 2003 Feb 1;254(1):116-30
Assay type: RNA in situ
MGI Accession ID: MGI:3605459
Gene symbol: Gdf5
Gene name: growth differentiation factor 5
Probe: Gdf5 probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: elbow joint primordium Strong 1A
TS21: shoulder joint primordium Strong 1A
TS21: forelimb Strong Regionally restricted 1A Expression is in the wrist joint.
TS21: forelimb digit Strong Regionally restricted 1A Expression is in interphalangeal joints of the digits.

Specimen 1C: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: knee joint primordium Strong 1C
TS22: hindlimb Strong Regionally restricted 1C Expression is in the ankle joint.
TS22: hindlimb digit Strong Regionally restricted 1C Expression is in interphalangeal joints of the digits.

Specimen 3C WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb cartilage condensation Present 3C

Specimen 3G Mut: embryonic day 14.5; Gdf6tm1Kng/Gdf6tm1Kng (more )
Structure Level Pattern Image Note
TS22: forelimb cartilage condensation Present 3G

Specimen 3K WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: talus Present Regionally restricted 3K Expression is in the joint.
TS23: tarsus Present Regionally restricted 3K Expression is in the joint.

Specimen 3O Mut: embryonic day 15.5; Gdf6tm1Kng/Gdf6tm1Kng (more )
Structure Level Pattern Image Note
TS23: talus Present Regionally restricted 3O Partial or incomplete expression in the joint.
TS23: tarsus Present Regionally restricted 3O Partial or incomplete expression in the joint.

Specimen Not Shown: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: vault of skull Absent Expression is absent in the sutures.

Specimen 7H: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: vertebra Present Regionally restricted 7H Expression is in stripes corresponding to the forming joints between the vertebrae.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory