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Gene Expression Data
Assay Details
Assay
Reference: J:47700 Greene ND, et al., Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects. Mech Dev. 1998 Apr;73(1):59-72
Assay type: RNA in situ
MGI Accession ID: MGI:3529948
Gene symbol: Notch1
Gene name: notch 1
Probe: Notch cDNA
Probe preparation: Antisense RNA
Results
Specimen 7A +/+: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: trunk unsegmented mesenchyme Present 7A +/+ Expression is present in a band at the rostral end of the presomitic mesoderm just caudal to the most recently formed somite.
Specimen 7A Lp/+: embryonic day 8.5; Vangl2Lp/Vangl2+ (more )
Structure Level Pattern Image Note
TS13: trunk paraxial mesenchyme Present 7A Lp/+ Expression in heterozygotes is intermediate compared to what is seen in homozygotes and wild type.
Specimen 7A Lp/Lp: embryonic day 8.5; Vangl2Lp/Vangl2Lp (more )
Structure Level Pattern Image Note
TS13: trunk paraxial mesenchyme Present 7A Lp/Lp Expression in homozygotes is markedly weaker and less well circumscribed than what is seen in wild type.
Specimen 7B +/+: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: tail unsegmented mesenchyme Present 7B +/+ Expression is present in a band at the rostral end of the presomitic mesoderm just caudal to the most recently formed somite.
Specimen 7B Lp/+: embryonic day 9.5; Vangl2Lp/Vangl2+ (more )
Structure Level Pattern Image Note
TS15: trunk paraxial mesenchyme Present 7B Lp/+ Expression in heterozygotes is intermediate compared to what is seen in homozygotes and wild type.
Specimen 7B Lp/Lp: embryonic day 9.5; Vangl2Lp/Vangl2Lp (more )
Structure Level Pattern Image Note
TS15: trunk paraxial mesenchyme Present 7B Lp/Lp Expression in homozygotes is markedly weaker and less well circumscribed than what is seen in wild type.
Specimen 7C: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: trunk paraxial mesenchyme Present 7C
Specimen 7D: embryonic day 9.5; Vangl2Lp/Vangl2Lp (more )
Structure Level Pattern Image Note
TS15: trunk paraxial mesenchyme Present 7D Expression levels are reduced in mutants compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory